| Literature DB >> 1565290 |
Abstract
1-Alpha, 25-dihydroxyvitamin D3, tumor necrosis factor alpha, and gamma-interferon induce sphingomyelin turnover to ceramide in HL-60 cells. The time frame of the turnover is consistent with ceramide formation being a mediator of growth and differentiation; furthermore, differentiation can be induced by addition of exogenous ceramides alone. Hence, the action of the biologically active form of vitamin D and other nutritionally relevant factors may be mediated by lipid second messenger pathways involving sphingolipids.Entities:
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Year: 1992 PMID： 1565290 DOI： 10.1111/j.1753-4887.1992.tb01273.x
Source DB: PubMed Journal: Nutr Rev ISSN： 0029-6643 Impact factor: 7.110