PURPOSE: To reveal the pathogenesis of myopic foveoschisis (MF). DESIGN: Clinicopathological report. METHODS: Internal limiting membranes (ILMs) were collected from ten patients with MF and five patients with idiopathic macular hole (IMH) as a control. Samples were subjected to transmission electron microscopic study. Characteristics of the ILM were compared between the two groups. RESULTS: Collagen fiber and cell debris were identified on the inner surface of ILM in seven eyes (70%) with MF, significantly more (P < .05) than found in IMH subjects (0%). More fibrous glial cells were likely to be found on the inner surface of ILM. No significant difference in fibroblast-like cell adhesion was observed. CONCLUSIONS: Collagen fiber and cellular component are suggested to play an important role in developing MF. ILM peeling may be essential for vitrectomy for MF.
PURPOSE: To reveal the pathogenesis of myopic foveoschisis (MF). DESIGN: Clinicopathological report. METHODS: Internal limiting membranes (ILMs) were collected from ten patients with MF and five patients with idiopathic macular hole (IMH) as a control. Samples were subjected to transmission electron microscopic study. Characteristics of the ILM were compared between the two groups. RESULTS: Collagen fiber and cell debris were identified on the inner surface of ILM in seven eyes (70%) with MF, significantly more (P < .05) than found in IMH subjects (0%). More fibrous glial cells were likely to be found on the inner surface of ILM. No significant difference in fibroblast-like cell adhesion was observed. CONCLUSIONS: Collagen fiber and cellular component are suggested to play an important role in developing MF. ILM peeling may be essential for vitrectomy for MF.
Authors: Giancarlo Sborgia; Francesco Boscia; Alfredo Niro; Ermete Giancipoli; Giuseppe D'Amico Ricci; Alessandra Sborgia; Luigi Sborgia; Nicola Recchimurzo; Mario R Romano; Giuseppe Addabbo; Giovanni Alessio Journal: Eye (Lond) Date: 2019-06-17 Impact factor: 3.775
Authors: Andreas Bringmann; Martin Karol; Jan Darius Unterlauft; Thomas Barth; Renate Wiedemann; Leon Kohen; Matus Rehak; Peter Wiedemann Journal: Int J Ophthalmol Date: 2021-06-18 Impact factor: 1.779