Literature DB >> 15652402

Effects of interferon-beta on the cytokine production of astrocytes.

Kazumasa Okada1, Etsushi Kuroda, Yasuhiro Yoshida, Uki Yamashita, Akio Suzumura, Sadatoshi Tsuji.   

Abstract

The effects of interferon (IFN)-beta used for treatment of multiple sclerosis (MS) on the central nervous system (CNS) have not yet been elucidated. The effect of IFN-beta and IFN-gamma on astrocytes as the major component of the CNS was investigated using murine primary astrocytes and human astrocytoma U251 cell line. IL-1beta, IL-6, TNF-alpha and iNOS were analyzed by RT-PCR. Both protein and mRNA levels of IL-6 were increased by IFN-beta. IFN-gamma augmented the effect of IFN-beta on IL-6 production. These results suggest that IFN-beta has an activity to modulate inflammatory and immune responses by up-regulating IL-6 in the CNS of MS.

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Year:  2004        PMID： 15652402     DOI： 10.1016/j.jneuroim.2004.09.013

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  6 in total

1.  Apyrase and 5'-nucleotidase activities in synaptosomes from the cerebral cortex of rats experimentally demyelinated with ethidium bromide and treated with interferon-beta.

Authors:  R M M Spanevello; C M Mazzanti; R Kaizer; R Zanin; D Cargnelutti; L Hannel; M Côrrea; A Mazzanti; R Festugatto; D Graça; M R C Schetinger; V M Morsch
Journal:  Neurochem Res       Date:  2006-05-13       Impact factor: 3.996

2.  Expression and functional significance of SOCS-1 and SOCS-3 in astrocytes.

Authors:  Hongwei Qin; Sandrine A Niyongere; Sun Jung Lee; Brandi J Baker; Etty N Benveniste
Journal:  J Immunol       Date:  2008-09-01       Impact factor: 5.422

3.  Acetylcholinesterase activity in rats experimentally demyelinated with ethidium bromide and treated with interferon beta.

Authors:  C M Mazzanti; R M Spanevello; L B Pereira; J F Gonçalves; R Kaizer; M Corrêa; M Ahmed; A Mazzanti; R Festugatto; D L Graça; V M Morsch; M R C Schetinger
Journal:  Neurochem Res       Date:  2006-07-27       Impact factor: 3.996

4.  Type I IFN signaling in T regulatory cells modulates chemokine production and myeloid derived suppressor cells trafficking during EAE.

Authors:  Shalini Tanwar; Cihan Oguz; Amina Metidji; Eric Dahlstrom; Kent Barbian; Kishore Kanakabandi; Lydia Sykora; Ethan M Shevach
Journal:  J Autoimmun       Date:  2020-07-22       Impact factor: 7.094

5.  [Primary headaches and the influence of inflammatory diseases of the CNS and their respective immunmodulatory therapy].

Authors:  M Empl; A Straube
Journal:  Schmerz       Date:  2007-10       Impact factor: 1.107

6.  Ifit2 deficiency results in uncontrolled neurotropic coronavirus replication and enhanced encephalitis via impaired alpha/beta interferon induction in macrophages.

Authors:  Niranjan B Butchi; David R Hinton; Stephen A Stohlman; Parul Kapil; Volker Fensterl; Ganes C Sen; Cornelia C Bergmann
Journal:  J Virol       Date:  2013-11-06       Impact factor: 5.103
  6 in total

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