BACKGROUND: To report the protracted 9-year survival of a patient after surgical management of multiple liver metastases from uveal melanoma. DESIGN: Interventional case report. METHODS: A 30-year-old patient, treated for choroidal melanoma by proton beam therapy, was semiannually followed by abdominal ultrasonography. Two years after initial treatment, a total body computed tomography scan suggested the diagnosis of isolated liver metastases. RESULTS: Multiple wedge resections and postoperative intra-arterial chemotherapy with fotemustine were performed. After 4 years, a metastatic nodule in the head of the pancreas was detected and surgically removed. Eighteen months later, metastases were progressively detected in other organs. The patient finally died of carcinomatous meningitis 9 years of first treatment of metastases. CONCLUSIONS: In the present case, the surgical control of liver metastases associated with intra-arterial chemotherapy prolonged the quality and length of life with progressive disease extension to other organs.
BACKGROUND: To report the protracted 9-year survival of a patient after surgical management of multiple liver metastases from uveal melanoma. DESIGN: Interventional case report. METHODS: A 30-year-old patient, treated for choroidal melanoma by proton beam therapy, was semiannually followed by abdominal ultrasonography. Two years after initial treatment, a total body computed tomography scan suggested the diagnosis of isolated liver metastases. RESULTS: Multiple wedge resections and postoperative intra-arterial chemotherapy with fotemustine were performed. After 4 years, a metastatic nodule in the head of the pancreas was detected and surgically removed. Eighteen months later, metastases were progressively detected in other organs. The patient finally died of carcinomatous meningitis 9 years of first treatment of metastases. CONCLUSIONS: In the present case, the surgical control of liver metastases associated with intra-arterial chemotherapy prolonged the quality and length of life with progressive disease extension to other organs.
Authors: R J Salmon; C Levy; C Plancher; T Dorval; L Desjardins; S Leyvraz; P Pouillart; P Schlienger; V Servois; B Asselain Journal: Eur J Surg Oncol Date: 1998-04 Impact factor: 4.424
Authors: T Aoyama; M J Mastrangelo; D Berd; F E Nathan; C L Shields; J A Shields; E L Rosato; F E Rosato; T Sato Journal: Cancer Date: 2000-10-01 Impact factor: 6.860
Authors: E S Gragoudas; K M Egan; J M Seddon; R J Glynn; S M Walsh; S M Finn; J E Munzenrider; M D Spar Journal: Ophthalmology Date: 1991-03 Impact factor: 12.079