Literature DB >> 15649818

Medulloblastoma: developmental mechanisms out of control.

Silvia Marino1.   

Abstract

Medulloblastoma, which is a highly aggressive central nervous system neoplasm, represents an intriguing example of how deregulated developmental mechanisms can lead to tumour development. Recent advances in the understanding of the role of Sonic Hedgehog, Wnt and Notch signalling pathways in the development of the cerebellum have shed new light on medulloblastoma pathogenesis.

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Year:  2005        PMID： 15649818     DOI： 10.1016/j.molmed.2004.11.008

Source DB:  PubMed          Journal:  Trends Mol Med        ISSN： 1471-4914            Impact factor:   11.951


  80 in total

Review 1.  Genetic and molecular alterations across medulloblastoma subgroups.

Authors:  Patryk Skowron; Vijay Ramaswamy; Michael D Taylor
Journal:  J Mol Med (Berl)       Date:  2015-09-09       Impact factor: 4.599

2.  VMY-1-103 is a novel CDK inhibitor that disrupts chromosome organization and delays metaphase progression in medulloblastoma cells.

Authors:  Lymor Ringer; Paul Sirajuddin; Mary Heckler; Anup Ghosh; Frank Suprynowicz; Venkata M Yenugonda; Milton L Brown; Jeffrey A Toretsky; Aykut Uren; YiChien Lee; Tobey J MacDonald; Olga Rodriguez; Robert I Glazer; Richard Schlegel; Chris Albanese
Journal:  Cancer Biol Ther       Date:  2011-11-01       Impact factor: 4.742

Review 3.  Development and cancer of the cerebellum.

Authors:  Mary E Hatten; Martine F Roussel
Journal:  Trends Neurosci       Date:  2011-03       Impact factor: 13.837

4.  Pyruvate Kinase Inhibits Proliferation during Postnatal Cerebellar Neurogenesis and Suppresses Medulloblastoma Formation.

Authors:  Katherine Tech; Andrey P Tikunov; Hamza Farooq; A Sorana Morrissy; Jessica Meidinger; Taylor Fish; Sarah C Green; Hedi Liu; Yisu Li; Andrew J Mungall; Richard A Moore; Yussanne Ma; Steven J M Jones; Marco A Marra; Matthew G Vander Heiden; Michael D Taylor; Jeffrey M Macdonald; Timothy R Gershon
Journal:  Cancer Res       Date:  2017-05-17       Impact factor: 12.701

5.  Two tumor suppressors, p27Kip1 and patched-1, collaborate to prevent medulloblastoma.

Authors:  Olivier Ayrault; Frederique Zindy; Jerold Rehg; Charles J Sherr; Martine F Roussel
Journal:  Mol Cancer Res       Date:  2009-01       Impact factor: 5.852

6.  YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation.

Authors:  Africa Fernandez-L; Paul A Northcott; James Dalton; Charles Fraga; David Ellison; Stephane Angers; Michael D Taylor; Anna Marie Kenney
Journal:  Genes Dev       Date:  2009-12-01       Impact factor: 11.361

7.  Post-transcriptional down-regulation of Atoh1/Math1 by bone morphogenic proteins suppresses medulloblastoma development.

Authors:  Haotian Zhao; Olivier Ayrault; Frederique Zindy; Jee-Hae Kim; Martine F Roussel
Journal:  Genes Dev       Date:  2008-03-15       Impact factor: 11.361

8.  MicroRNA 128a increases intracellular ROS level by targeting Bmi-1 and inhibits medulloblastoma cancer cell growth by promoting senescence.

Authors:  Sujatha Venkataraman; Irina Alimova; Rong Fan; Peter Harris; Nicholas Foreman; Rajeev Vibhakar
Journal:  PLoS One       Date:  2010-06-21       Impact factor: 3.240

9.  An investigation of WNT pathway activation and association with survival in central nervous system primitive neuroectodermal tumours (CNS PNET).

Authors:  H A Rogers; S Miller; J Lowe; M-A Brundler; B Coyle; R G Grundy
Journal:  Br J Cancer       Date:  2009-03-17       Impact factor: 7.640

10.  MicroRNA-199b-5p impairs cancer stem cells through negative regulation of HES1 in medulloblastoma.

Authors:  Livia Garzia; Immacolata Andolfo; Emilio Cusanelli; Natascia Marino; Giuseppe Petrosino; Daniela De Martino; Veronica Esposito; Aldo Galeone; Luigi Navas; Silvia Esposito; Sara Gargiulo; Sarah Fattet; Vittoria Donofrio; Giuseppe Cinalli; Arturo Brunetti; Luigi Del Vecchio; Paul A Northcott; Olivier Delattre; Michael D Taylor; Achille Iolascon; Massimo Zollo
Journal:  PLoS One       Date:  2009-03-24       Impact factor: 3.240
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