Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Engulfment: ingestion and migration with Rac, Rho and TRIO.

Literature DB >> 15649349

Engulfment: ingestion and migration with Rac, Rho and TRIO.

Abstract

Apoptotic cells are removed from tissues by uptake mechanisms that depend on the GTPase Rac (CED-10 in C. elegans), which is activated by DOCK180/CED-5 in a trimolecular complex with ELMO/CED-12 and CrkII/CED-2. A study now identifies upstream components of this pathway in both worms and mammalian cells involving yet another GTPase, RhoG/MIG-2, and its activator TRIO/UNC-73.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 2005 PMID： 15649349 DOI： 10.1016/j.cub.2004.12.017

Source DB: PubMed Journal: Curr Biol ISSN： 0960-9822 Impact factor: 10.834

Keyword Cloud
Cited

15 in total

1. Lipopolysaccharide inhibits macrophage phagocytosis of apoptotic neutrophils by regulating the production of tumour necrosis factor α and growth arrest-specific gene 6.

Authors: Xueying Feng; Tingting Deng; Yue Zhang; Shaobo Su; Chiju Wei; Daishu Han
Journal: Immunology Date: 2010-10-29 Impact factor: 7.397

Engulfment: ingestion and migration with Rac, Rho and TRIO.

1. Lipopolysaccharide inhibits macrophage phagocytosis of apoptotic neutrophils by regulating the production of tumour necrosis factor α and growth arrest-specific gene 6.

2. A minimal Rac activation domain in the unconventional guanine nucleotide exchange factor Dock180.

3. Rho-guanine nucleotide exchange factors during development: Force is nothing without control.

4. G protein α₁₂ (Gα₁₂) is a negative regulator of kidney injury molecule-1-mediated efferocytosis.

5. Prenylation and membrane localization of Cdc42 are essential for activation by DOCK7.

6. A pathway for phagosome maturation during engulfment of apoptotic cells.

7. Unfolded protein response genes regulated by CED-1 are required for Caenorhabditis elegans innate immunity.

Review 8. Rho GTPases, phosphoinositides, and actin: a tripartite framework for efficient vesicular trafficking.

9. Transcriptional and translational regulation of TGF-beta production in response to apoptotic cells.

10. The guanine nucleotide exchange factors trio, Ect2, and Vav3 mediate the invasive behavior of glioblastoma.