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Literature DB >> 15649133

Dynamin I phosphorylation and the control of synaptic vesicle endocytosis.

Abstract

The GTPase dynamin I is essential for synaptic vesicle endocytosis in nerve terminals. It is a nerve terminal phosphoprotein that is dephosphorylated on nerve terminal stimulation by the calcium-dependent protein phosphatase calcineurin and then rephosphorylated by cyclin-dependent kinase 5 on termination of the stimulus. Because of its unusual phosphorylation profile, the phosphorylation status of dynamin I was assumed to be inexorably linked to synaptic vesicle endocytosis; however, direct proof of this link has been elusive until very recently. This review will describe current knowledge regarding dynamin I phosphorylation in nerve terminals and how this regulates its biological function with respect to synaptic vesicle endocytosis.

Entities: Chemical

Mesh：

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Year: 2005 PMID： 15649133 PMCID： PMC2077358 DOI： 10.1042/bss0720087

Source DB: PubMed Journal: Biochem Soc Symp ISSN： 0067-8694

46 in total

1. GTPase activity of dynamin and resulting conformation change are essential for endocytosis.

Authors: B Marks; M H Stowell; Y Vallis; I G Mills; A Gibson; C R Hopkins; H T McMahon
Journal: Nature Date: 2001-03-08 Impact factor: 49.962

2. Amphiphysin 1 binds the cyclin-dependent kinase (cdk) 5 regulatory subunit p35 and is phosphorylated by cdk5 and cdc2.

Authors: S R Floyd; E B Porro; V I Slepnev; G C Ochoa; L H Tsai; P De Camilli
Journal: J Biol Chem Date: 2000-12-11 Impact factor: 5.157

3. Activation of dynamin GTPase activity by phosphoinositides and SH3 domain-containing proteins.

Authors: B Barylko; D D Binns; J P Albanesi
Journal: Methods Enzymol Date: 2001 Impact factor: 1.600

Review 4. Synaptic vesicle endocytosis: calcium works overtime in the nerve terminal.

Authors: M A Cousin
Journal: Mol Neurobiol Date: 2000 Aug-Dec Impact factor: 5.590

5. The calcineurin-binding protein cain is a negative regulator of synaptic vesicle endocytosis.

Authors: M M Lai; H R Luo; P E Burnett; J J Hong; S H Snyder
Journal: J Biol Chem Date: 2000-11-03 Impact factor: 5.157

6. Nucleotide-dependent conformational changes in dynamin: evidence for a mechanochemical molecular spring.

Authors: M H Stowell; B Marks; P Wigge; H T McMahon
Journal: Nat Cell Biol Date: 1999-05 Impact factor: 28.824

7. Cdk5/p25(nck5a) interaction with synaptic proteins in bovine brain.

Authors: J L Rosales; M J Nodwell; R N Johnston; K Y Lee
Journal: J Cell Biochem Date: 2000-04 Impact factor: 4.429

8. Protein phosphorylation is required for endocytosis in nerve terminals: potential role for the dephosphins dynamin I and synaptojanin, but not AP180 or amphiphysin.

Authors: M A Cousin; T C Tan; P J Robinson
Journal: J Neurochem Date: 2001-01 Impact factor: 5.372

Review 9. A decade of CDK5.

Authors: R Dhavan; L H Tsai
Journal: Nat Rev Mol Cell Biol Date: 2001-10 Impact factor: 94.444

10. Phosphorylation of dynamin I on Ser-795 by protein kinase C blocks its association with phospholipids.

Authors: K A Powell; V A Valova; C S Malladi; O N Jensen; M R Larsen; P J Robinson
Journal: J Biol Chem Date: 2000-04-21 Impact factor: 5.157

20 in total

1. Slm1 and slm2 are novel substrates of the calcineurin phosphatase required for heat stress-induced endocytosis of the yeast uracil permease.

Authors: Geert Bultynck; Victoria L Heath; Alia P Majeed; Jean-Marc Galan; Rosine Haguenauer-Tsapis; Martha S Cyert
Journal: Mol Cell Biol Date: 2006-06 Impact factor: 4.272

2. Differential curvature sensing and generating activities of dynamin isoforms provide opportunities for tissue-specific regulation.

Authors: Ya-Wen Liu; Sylvia Neumann; Rajesh Ramachandran; Shawn M Ferguson; Thomas J Pucadyil; Sandra L Schmid
Journal: Proc Natl Acad Sci U S A Date: 2011-06-13 Impact factor: 11.205

3. The Rhodadyns, a New Class of Small Molecule Inhibitors of Dynamin GTPase Activity.

Authors: Mark J Robertson; Gordana Hadzic; Joseph Ambrus; D Yuri Pomè; Emily Hyde; Ainslie Whiting; Anna Mariana; Lisa von Kleist; Ngoc Chau; Volker Haucke; Phillip J Robinson; Adam McCluskey
Journal: ACS Med Chem Lett Date: 2012-03-26 Impact factor: 4.345

4. Differential targeting of dynamin-1 and dynamin-3 to nerve terminals during chronic suppression of neuronal activity.

Authors: Barbara Calabrese; Shelley Halpain
Journal: Mol Cell Neurosci Date: 2015-03-27 Impact factor: 4.314

5. Endplate structure and parameters of neuromuscular transmission in sporadic centronuclear myopathy associated with myasthenia.

Authors: Teerin Liewluck; Xin-Ming Shen; Margherita Milone; Andrew G Engel
Journal: Neuromuscul Disord Date: 2011-04-08 Impact factor: 4.296