Literature DB >> 15649022

The interaction between levofloxacine hydrochloride and DNA mediated by Cu2+.

Gongwu Song1, Yu He, Zhaoxia Cai.   

Abstract

Levofloxacin (LEV) is a fluoroquinolone antimicrobial agent. LEV also inhibits DNA synthesis and is bactericidal. The mechanisms of the interaction among LEV, DNA and Cu2+ are studied by fluorescence method. In the paper, the results show that LEV and Cu2+ can form binary complex, and also LEV and DNA can form complex mediated by Cu2+. The composition of the complex is determined. The affects to the reaction are also found.

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Year:  2004        PMID： 15649022     DOI： 10.1023/b:jofl.0000047220.92976.50

Source DB:  PubMed          Journal:  J Fluoresc        ISSN： 1053-0509            Impact factor:   2.217


  8 in total

1.  Fluorescence characteristic study of the ternary complex of fluoroquinolone antibiotics and cobalt (II) with ATP.

Authors:  S Wu; W Zhang; X Chen; Z Hu; M Hooper; B Hooper; Z Zhao
Journal:  Spectrochim Acta A Mol Biomol Spectrosc       Date:  2001-05       Impact factor: 4.098

Review 2.  The molecular basis of quinolone action.

Authors:  A Maxwell
Journal:  J Antimicrob Chemother       Date:  1992-10       Impact factor: 5.790

3.  Electrochemical studies of NiTMpyP and interaction with DNA.

Authors:  F Qu; N Q Li; Y Y Jiang
Journal:  Talanta       Date:  1998-03       Impact factor: 6.057

4.  [Study on the ternary complex of CPFX, copper (II) and DNA by the method of fluorescence].

Authors:  X Yuan; L Chen; J Qiao
Journal:  Guang Pu Xue Yu Guang Pu Fen Xi       Date:  1999-08       Impact factor: 0.589

5.  The orientation of norfloxacin bound to double-stranded DNA.

Authors:  C Bailly; P Colson; C Houssier
Journal:  Biochem Biophys Res Commun       Date:  1998-02-24       Impact factor: 3.575

6.  Mg(2+)-mediated binding of 6-substituted quinolones to DNA: relevance to biological activity.

Authors:  C Sissi; M Andreolli; V Cecchetti; A Fravolini; B Gatto; M Palumbo
Journal:  Bioorg Med Chem       Date:  1998-09       Impact factor: 3.641

7.  Mechanistic study of inhibition of levofloxacin absorption by aluminum hydroxide.

Authors:  M Tanaka; T Kurata; C Fujisawa; Y Ohshima; H Aoki; O Okazaki; H Hakusui
Journal:  Antimicrob Agents Chemother       Date:  1993-10       Impact factor: 5.191

8.  Studies on the interaction of 4-quinolones with DNA by DNA unwinding experiments.

Authors:  S Tornaletti; A M Pedrini
Journal:  Biochim Biophys Acta       Date:  1988-03-31
  8 in total
  5 in total

1.  Cu(Nor)2·5H2O, a complex of Cu(II) with Norfloxacin: theoretic approach and biological studies. Cytotoxicity and genotoxicity in cell cultures.

Authors:  A L Di Virgilio; I E León; C A Franca; I Henao; G Tobón; S B Etcheverry
Journal:  Mol Cell Biochem       Date:  2012-12-14       Impact factor: 3.396

2.  Influence of Mg+2 and Cu+2 on the interaction between quinolone and calf thymus DNA.

Authors:  Dong-Sheng Guo; Bo-Yu Jing; Xiao-Ying Yuan
Journal:  J Fluoresc       Date:  2010-07-03       Impact factor: 2.217

3.  Interaction between Pazufloxacin and DNA mediated by copper(II) ions.

Authors:  Guoliang Zhang; Xuchun Fu; Qingwang Liu; Guoping Wang
Journal:  J Fluoresc       Date:  2008-02-22       Impact factor: 2.217

Review 4.  Metal complexes of quinolone antibiotics and their applications: an update.

Authors:  Valentina Uivarosi
Journal:  Molecules       Date:  2013-09-11       Impact factor: 4.411

5.  Probing the Characterization of the Interaction of Aflatoxins B1 and G1 with Calf Thymus DNA In Vitro.

Authors:  Liang Ma; Jiaman Wang; Yuhao Zhang
Journal:  Toxins (Basel)       Date:  2017-07-01       Impact factor: 4.546
  5 in total

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