Literature DB >> 15648031

Renal function in space: the link between osteoporosis, hypercalciuria, and aquaporins.

Natale Gaspare De Santo1, Massimo Cirillo, Giovanna Valenti, Alessandra Perna, Pietro Anastasio, Christian Drummer.   

Abstract

This article reviews bone adaptation to microgravity, during manned space missions, in humans undergoing Head Down Tilt (HDT) and in Hind-Limb-Suspended Rats. Under microgravity conditions, bone loss occurs in association with hypercalciuria, which in turn modulates Aquaporin 2 (AQP2) excretion in urine, thus avoiding stone forming in space. This report discloses the need to prevent bone loss in order to prepare for long stays at lunar bases or voyages to Mars.

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Year:  2005        PMID： 15648031     DOI： 10.1053/j.jrn.2004.09.011

Source DB:  PubMed          Journal:  J Ren Nutr        ISSN： 1051-2276            Impact factor:   3.655


  6 in total

Review 1.  The kidney in space.

Authors:  Vassilios Liakopoulos; Konstantinos Leivaditis; Theodoros Eleftheriadis; Nicholas Dombros
Journal:  Int Urol Nephrol       Date:  2012-09-22       Impact factor: 2.370

2.  Study of histopathological and molecular changes of rat kidney under simulated weightlessness and resistance training protective effect.

Authors:  Ye Ding; Jun Zou; Zhili Li; Jijing Tian; Saed Abdelalim; Fang Du; Ruiping She; Desheng Wang; Cheng Tan; Huijuan Wang; Wenjuan Chen; Dongqiang Lv; Lingling Chang
Journal:  PLoS One       Date:  2011-05-23       Impact factor: 3.240

Review 3.  Oxidative Stress and the Kidney in the Space Environment.

Authors:  Paraskevi Pavlakou; Evangelia Dounousi; Stefanos Roumeliotis; Theodoros Eleftheriadis; Vassilios Liakopoulos
Journal:  Int J Mol Sci       Date:  2018-10-15       Impact factor: 5.923

4.  Early Biomarkers of Altered Renal Function and Orthostatic Intolerance During 10-day Bedrest.

Authors:  Grazia Tamma; Annarita Di Mise; Marianna Ranieri; Mariangela Centrone; Maria Venneri; Mariagrazia D'Agostino; Angela Ferrulli; Boštjan Šimunič; Marco Narici; Rado Pisot; Giovanna Valenti
Journal:  Front Physiol       Date:  2022-04-20       Impact factor: 4.755

5.  Leukocyte activity is altered in a ground based murine model of microgravity and proton radiation exposure.

Authors:  Jenine K Sanzari; Ana L Romero-Weaver; Gabrielle James; Gabriel Krigsfeld; Liyong Lin; Eric S Diffenderfer; Ann R Kennedy
Journal:  PLoS One       Date:  2013-08-14       Impact factor: 3.240

6.  A decrease in aquaporin 2 excretion is associated with bed rest induced high calciuria.

Authors:  Grazia Tamma; Annarita Di Mise; Marianna Ranieri; Maria Svelto; Rado Pisot; Giancarlo Bilancio; Pierpaolo Cavallo; Natale G De Santo; Massimo Cirillo; Giovanna Valenti
Journal:  J Transl Med       Date:  2014-05-19       Impact factor: 5.531
  6 in total

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