Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Breakdown of axonal synaptic vesicle precursor transport by microglial nitric oxide.

Literature DB >> 15647478

Breakdown of axonal synaptic vesicle precursor transport by microglial nitric oxide.

Massimiliano Stagi¹, Petra S Dittrich, Nadja Frank, Asparouh I Iliev, Petra Schwille, Harald Neumann.

Abstract

The mechanism of axonal injury in inflammatory brain diseases is still unclear. Increased microglial production of nitric oxide (NO) is a common early sign in neuroinflammatory diseases. We found by fluorescence correlation spectroscopy that synaptophysin tagged with enhanced green fluorescence protein (synaptophysin-EGFP) moves anterogradely in axons of cultured neurons. Activated microglia focally inhibited the axonal movement of synaptophysin-EGFP in a NO synthase-dependent manner. Direct application of a NO donor to neurons resulted in inhibition of axonal transport of synaptophysin-EGFP and synaptotagmin I tagged with EGFP, mediated via phosphorylation of c-jun NH2-terminal kinase (JNK). Thus, overt production of reactive NO by activated microglia blocks the axonal transport of synaptic vesicle precursors via phosphorylation of JNK and could cause axonal and synaptic dysfunction.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2005 PMID： 15647478 PMCID： PMC6725475 DOI： 10.1523/JNEUROSCI.3887-04.2005

Source DB: PubMed Journal: J Neurosci ISSN： 0270-6474 Impact factor: 6.167

33 in total

1. Transduction. When worlds collide--trafficking in JNK.

Authors: L S Goldstein
Journal: Science Date: 2001-03-16 Impact factor: 47.728

2. Axonal membrane proteins are transported in distinct carriers: a two-color video microscopy study in cultured hippocampal neurons.

Authors: C Kaether; P Skehel; C G Dotti
Journal: Mol Biol Cell Date: 2000-04 Impact factor: 4.138

Review 3. Accessing molecular dynamics in cells by fluorescence correlation spectroscopy.

Authors: P Dittrich; F Malvezzi-Campeggi; M Jahnz; P Schwille
Journal: Biol Chem Date: 2001-03 Impact factor: 3.915

4. Transcription activator protein 1 (AP-1) mediates NO-induced apoptosis of adult cardiomyocytes.

Authors: G Taimor; A Rakow; H M Piper
Journal: FASEB J Date: 2001-09-17 Impact factor: 5.191

5. Acute axonal injury in multiple sclerosis. Correlation with demyelination and inflammation.

Authors: A Bitsch; J Schuchardt; S Bunkowski; T Kuhlmann; W Brück
Journal: Brain Date: 2000-06 Impact factor: 13.501

6. Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein.

Authors: A B Bowman; A Kamal; B W Ritchings; A V Philp; M McGrail; J G Gindhart; L S Goldstein
Journal: Cell Date: 2000-11-10 Impact factor: 41.582

7. Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions.

Authors: J W Peterson; L Bö; S Mörk; A Chang; B D Trapp
Journal: Ann Neurol Date: 2001-09 Impact factor: 10.422

8. UNC-16, a JNK-signaling scaffold protein, regulates vesicle transport in C. elegans.

Authors: D T Byrd; M Kawasaki; M Walcoff; N Hisamoto; K Matsumoto; Y Jin
Journal: Neuron Date: 2001-12-06 Impact factor: 17.173

9. Evidence for peroxynitrite as a signaling molecule in flow-dependent activation of c-Jun NH(2)-terminal kinase.

Authors: Y M Go; R P Patel; M C Maland; H Park; J S Beckman; V M Darley-Usmar; H Jo
Journal: Am J Physiol Date: 1999-10

10. Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules.

Authors: K J Verhey; D Meyer; R Deehan; J Blenis; B J Schnapp; T A Rapoport; B Margolis
Journal: J Cell Biol Date: 2001-03-05 Impact factor: 10.539

26 in total

1. Lack of neuroprotection against experimental glaucoma in c-Jun N-terminal kinase 3 knockout mice.

Authors: Harry A Quigley; Frances E Cone; Scott E Gelman; Zhiyong Yang; Janice L Son; Ericka N Oglesby; Mary E Pease; Donald J Zack
Journal: Exp Eye Res Date: 2011-01-25 Impact factor: 3.467

2. Determination of axonal transport velocities via image cross- and autocorrelation.

Authors: Oliver Welzel; Daniel Boening; Armin Stroebel; Udo Reulbach; Jurgen Klingauf; Johannes Kornhuber; Teja Wolfgang Groemer
Journal: Eur Biophys J Date: 2009-04-30 Impact factor: 1.733

Review 3. Role of microglia in neuronal degeneration and regeneration.

Authors: Lisa Walter; Harald Neumann
Journal: Semin Immunopathol Date: 2009-09-09 Impact factor: 9.623

4. T-cell-mediated disruption of the neuronal microtubule network: correlation with early reversible axonal dysfunction in acute experimental autoimmune encephalomyelitis.

Authors: Leah P Shriver; Bonnie N Dittel
Journal: Am J Pathol Date: 2006-09 Impact factor: 4.307

5. IL-6 induces regionally selective spinal cord injury in patients with the neuroinflammatory disorder transverse myelitis.

Authors: Adam I Kaplin; Deepa M Deshpande; Erick Scott; Chitra Krishnan; Jessica S Carmen; Irina Shats; Tara Martinez; Jennifer Drummond; Sonny Dike; Mikhail Pletnikov; Sanjay C Keswani; Timothy H Moran; Carlos A Pardo; Peter A Calabresi; Douglas A Kerr
Journal: J Clin Invest Date: 2005-09-22 Impact factor: 14.808