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Literature DB >> 15647005

Compartmental oxidation of thiol-disulphide redox couples during epidermal growth factor signalling.

Patrick J Halvey¹, Walter H Watson, Jason M Hansen, Young-Mi Go, Afshin Samali, Dean P Jones.

Abstract

Exogenously added ROS (reactive oxygen species) cause generalized oxidation of cellular components, whereas endogenously generated ROS induced by physiological stimuli activate discrete signal transduction pathways. Compartmentation is an important aspect of such pathways, but little is known about its role in redox signalling. We measured the redox states of cytosolic and nuclear Trx1 (thioredoxin-1) and mitochondrial Trx2 (thioredoxin-2) using redox Western blot methodologies during endogenous ROS production induced by EGF (epidermal growth factor) signalling. The glutathione redox state was measured by HPLC. Results showed that only cytosolic Trx1 undergoes significant oxidation. Thus EGF signalling involves subcellular compartmental oxidation of Trx1 in the absence of a generalized cellular oxidation.

Entities: Chemical Gene

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Year: 2005 PMID： 15647005 PMCID： PMC1134784 DOI： 10.1042/BJ20041829

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

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