| Literature DB >> 15645440 |
Michael L Gatza1, Chandtip Chandhasin, Razvan I Ducu, Susan J Marriott.
Abstract
It is estimated that 15% of all cancers are etiologically linked to viral infection. Specific cancers including adult T-cell leukemia, hepatocellular carcinoma, and uterine cervical cancer are associated with infection by human T-cell leukemia virus type I, hepatitis B virus, and high-risk human papilloma virus, respectively. In these cancers, genomic instability, a hallmark of multistep cancers, has been explicitly linked to the expression of oncoproteins encoded by these viruses. This review discusses mechanisms utilized by these viral oncoproteins, Tax, HBx, and E6/E7, to mediate genomic instability and cellular transformation.Entities:
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Year: 2005 PMID： 15645440 DOI： 10.1002/em.20088
Source DB: PubMed Journal: Environ Mol Mutagen ISSN： 0893-6692 Impact factor: 3.216