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Literature DB >> 15645343

Postnatal decrease in substantia nigra echogenicity. Implications for the pathogenesis of Parkinson's disease.

Alexander Iova¹, Andrew Garmashov, Natalia Androuchtchenko, Martin Kehrer, Daniela Berg, Georg Becker, Yurii Garmashov.

Abstract

Increased echogenicity of the substantia nigra (SN) on transcranial ultrasonography (TCS) is a typical sign in Parkinson's disease (PD). Detected in healthy adults it is assumed to represent a risk factor for nigral injury. We studied at which time point of brain maturation increased signal intensity may occur by performing TCS scans in 109 newborns and children aged 0-192 months. While newborns regularly exhibit SN hyperechogenicity, this echofeature decreases substantially during the first years of life. As SN echogenicity is related to the tissue iron content in adults our findings suggest a failure in SN iron metabolism in some children with increased echogenicity during development which can be disclosed by TCS.

Entities: Chemical Disease Species

Mesh：

Substances：
Iron

Year: 2004 PMID： 15645343 DOI： 10.1007/s00415-004-0556-3

Source DB: PubMed Journal: J Neurol ISSN： 0340-5354 Impact factor: 4.849

14 in total

1. Vulnerability of the nigrostriatal system as detected by transcranial ultrasound.

Authors: D Berg; G Becker; B Zeiler; O Tucha; E Hofmann; M Preier; P Benz; W Jost; K Reiners; K W Lange
Journal: Neurology Date: 1999-09-22 Impact factor: 9.910

2. Echogenicity of substantia nigra determined by transcranial ultrasound correlates with severity of parkinsonian symptoms induced by neuroleptic therapy.

Authors: D Berg; B Jabs; U Merschdorf; H Beckmann; G Becker
Journal: Biol Psychiatry Date: 2001-09-15 Impact factor: 13.382

3. Echogenicity of the substantia nigra in Parkinson's disease and its relation to clinical findings.

Authors: D Berg; C Siefker; G Becker
Journal: J Neurol Date: 2001-08 Impact factor: 4.849

4. Relationship of substantia nigra echogenicity and motor function in elderly subjects.

Authors: D Berg; C Siefker; P Ruprecht-Dörfler; G Becker
Journal: Neurology Date: 2001-01-09 Impact factor: 9.910

Review 5. Neuroimaging in basal ganglia disorders: perspectives for transcranial ultrasound.

Authors: G Becker; D Berg
Journal: Mov Disord Date: 2001-01 Impact factor: 10.338

6. Echogenicity of the substantia nigra: association with increased iron content and marker for susceptibility to nigrostriatal injury.

Authors: Daniela Berg; Wolfgang Roggendorf; Ute Schröder; Rüdiger Klein; Thomas Tatschner; Peter Benz; Oliver Tucha; Michael Preier; Klaus W Lange; Karlheinz Reiners; Manfred Gerlach; Georg Becker
Journal: Arch Neurol Date: 2002-06

7. Degeneration of substantia nigra in chronic Parkinson's disease visualized by transcranial color-coded real-time sonography.

Authors: G Becker; J Seufert; U Bogdahn; H Reichmann; K Reiners
Journal: Neurology Date: 1995-01 Impact factor: 9.910

8. Increased iron (III) and total iron content in post mortem substantia nigra of parkinsonian brain.

Authors: E Sofic; P Riederer; H Heinsen; H Beckmann; G P Reynolds; G Hebenstreit; M B Youdim
Journal: J Neural Transm Date: 1988 Impact factor: 3.575

9. Brain parenchyma sonography discriminates Parkinson's disease and atypical parkinsonian syndromes.

Authors: U Walter; L Niehaus; T Probst; R Benecke; B U Meyer; D Dressler
Journal: Neurology Date: 2003-01-14 Impact factor: 9.910

10. Iron, neuromelanin and ferritin content in the substantia nigra of normal subjects at different ages: consequences for iron storage and neurodegenerative processes.

Authors: L Zecca; M Gallorini; V Schünemann; A X Trautwein; M Gerlach; P Riederer; P Vezzoni; D Tampellini
Journal: J Neurochem Date: 2001-03 Impact factor: 5.372

9 in total

Review 1. Early diagnosis of Parkinson's disease.

Authors: Jörg Spiegel; Alexander Storch; Wolfgang H Jost
Journal: J Neurol Date: 2006-08 Impact factor: 4.849

Review 2. Movement disorders: neurodevelopment and neurobehavioural expression.

Authors: T Archer; R J Beninger
Journal: J Neural Transm (Vienna) Date: 2006-10-06 Impact factor: 3.575

Review 3. Advances in markers of prodromal Parkinson disease.

Authors: Ronald B Postuma; Daniela Berg
Journal: Nat Rev Neurol Date: 2016-10-27 Impact factor: 42.937

4. Cross-sectional study discloses a positive family history for Parkinson's disease and male gender as epidemiological risk factors for substantia nigra hyperechogenicity.

Authors: K J Schweitzer; S Behnke; I Liepelt; B Wolf; C Grosser; J Godau; A Gaenslen; T Bruessel; A Wendt; F Abel; A Müller; T Gasser; D Berg
Journal: J Neural Transm (Vienna) Date: 2007-04-20 Impact factor: 3.575

9. The predictive value of transcranial duplex sonography for the clinical diagnosis in undiagnosed parkinsonian syndromes: comparison with SPECT scans.

Authors: Annemarie M M Vlaar; Tjerk de Nijs; Marinus J P G van Kroonenburgh; Werner H Mess; Ania Winogrodzka; Selma C Tromp; Wim E J Weber
Journal: BMC Neurol Date: 2008-11-09 Impact factor: 2.474