Literature DB >> 15645193

[Generalized hyperpigmentation and malignant acanthosis nigricans. A case of a patient with hereditary hemochromatosis and gastric cancer].

A Kalt1, A Wagner, S Zeuzem, W Tilgen, J Reichrath.   

Abstract

A 56-year-old previously healthy man developed hyperpigmentation of the entire skin over the previous 6 months without any other signs of further impairment. Additionally, we found accentuated skin lines of the neck and intertriginous sites as well as cutaneous papillomatosis. Histological examinations, laboratory tests and technical diagnostics revealed the existence of both hereditary hemochromatosis and adenocarcinoma of the stomach. Simultaneous manifestation of hyperpigmentation as a result of hemochromatosis as well as malignant acanthosis nigricans as a paraneoplastic symptom in gastric cancer is very rare.

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Year:  2005        PMID: 15645193     DOI: 10.1007/s00105-004-0869-2

Source DB:  PubMed          Journal:  Hautarzt        ISSN: 0017-8470            Impact factor:   0.751


  19 in total

Review 1.  Coexistence of acanthosis nigricans and the sign of Leser-Trélat in a patient with gastric adenocarcinoma: a case report and literature review.

Authors:  J S Yeh; S E Munn; T A Plunkett; P G Harper; D J Hopster; A W du Vivier
Journal:  J Am Acad Dermatol       Date:  2000-02       Impact factor: 11.527

2.  Increased cancer risk in a cohort of 230 patients with hereditary hemochromatosis in comparison to matched control patients with non-iron-related chronic liver disease.

Authors:  A L Fracanzani; D Conte; M Fraquelli; E Taioli; M Mattioli; A Losco; S Fargion
Journal:  Hepatology       Date:  2001-03       Impact factor: 17.425

Review 3.  Mechanisms of iron accumulation in hereditary hemochromatosis.

Authors:  Robert E Fleming; William S Sly
Journal:  Annu Rev Physiol       Date:  2002       Impact factor: 19.318

Review 4.  Cutaneous manifestations of endocrine disorders: a guide for dermatologists.

Authors:  Serge A Jabbour
Journal:  Am J Clin Dermatol       Date:  2003       Impact factor: 7.403

Review 5.  Acanthosis nigricans with endometrial carcinoma: case report and review of the literature.

Authors:  Tarek M Mekhail; Maurie Markman
Journal:  Gynecol Oncol       Date:  2002-02       Impact factor: 5.482

Review 6.  [Acanthosis nigricans maligna. Case report and review of the literature].

Authors:  U Lenzner; J Ramsauer; W Petzoldt; W Meigel
Journal:  Hautarzt       Date:  1998-01       Impact factor: 0.751

Review 7.  Cutaneous paraneoplastic syndromes in solid tumors.

Authors:  R Kurzrock; P R Cohen
Journal:  Am J Med       Date:  1995-12       Impact factor: 4.965

8.  Florid cutaneous papillomatosis.

Authors:  R A Schwartz; G H Burgess
Journal:  Arch Dermatol       Date:  1978-12

9.  Acanthosis nigricans.

Authors:  R A Schwartz
Journal:  J Am Acad Dermatol       Date:  1994-07       Impact factor: 11.527

10.  Tripe palms: a cutaneous marker of internal malignancy.

Authors:  L Requena; A Aguilar; G Renedo; L Martín; E Piqué; M C Fariña; P Escalonilla
Journal:  J Dermatol       Date:  1995-07       Impact factor: 4.005

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