| Literature DB >> 15644191 |
Abstract
Extensive use of RNA interference in mammals has been hindered by the inability to effectively deliver small interfering RNAs (siRNAs) or DNA-based constructs designed to express siRNAs. In this chapter, we describe the high-pressure or hydrodynamic intravascular injection technique used to deliver these nucleic acids to mice and nonhuman primates. Emphasis is placed on the use of this technique for delivery to the liver.Entities:
Mesh：
Substances：
Year: 2005 PMID： 15644191 DOI： 10.1016/S0076-6879(04)92020-4
Source DB: PubMed Journal: Methods Enzymol ISSN： 0076-6879 Impact factor: 1.600