| Literature DB >> 15643898 |
Katrina M Miranda1, Andrew S Dutton, Lisa A Ridnour, Christian A Foreman, Eleonora Ford, Nazareno Paolocci, Tatsuo Katori, Carlo G Tocchetti, Daniele Mancardi, Douglas D Thomas, Michael G Espey, K N Houk, Jon M Fukuto, David A Wink.
Abstract
The recent determination that Angeli's salt may have clinical application as a nitrogen oxide donor for treatment of cardiovascular diseases such as heart failure has led to renewed interest in the mechanism and products of thermal decomposition of Angeli's salt under physiological conditions. In this report, several mechanisms are evaluated experimentally and by quantum mechanical calculations to determine whether HNO is in fact released from Angeli's salt in neutral, aerobic solution. The mechanism of product autoxidation is also considered.Entities:
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Year: 2005 PMID： 15643898 DOI： 10.1021/ja045480z
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419