BACKGROUND: An endemic fungal infection of the desert southwestern United States, coccidioidomycosis is generally a self-limited illness in healthy persons. Immunosuppressed persons who contract coccidioidomycosis, however, are at increased risk for disseminated infection. METHODS: We conducted a retrospective review of patients with coccidioidomycosis and hematologic malignancy or bone marrow disease. RESULTS: Fifty-five patients were identified. The most common underlying malignancies were non-Hodgkin lymphoma and chronic lymphocytic leukemia. Extrathoracic (or disseminated) infection was observed in 12 patients (22%). Fifteen patients (27%) died with active coccidioidomycosis. Treatment of the hematologic disease with corticosteroids or antineoplastic chemotherapy increased the risk of death. CONCLUSION: To date, this is the largest case series of patients with hematologic malignancy and coccidioidomycosis. In persons with hematologic malignancy, coccidioidomycosis can be a severe illness with a high risk for disseminated infection and death.
BACKGROUND: An endemic fungal infection of the desert southwestern United States, coccidioidomycosis is generally a self-limited illness in healthy persons. Immunosuppressed persons who contract coccidioidomycosis, however, are at increased risk for disseminated infection. METHODS: We conducted a retrospective review of patients with coccidioidomycosis and hematologic malignancy or bone marrow disease. RESULTS: Fifty-five patients were identified. The most common underlying malignancies were non-Hodgkin lymphoma and chronic lymphocytic leukemia. Extrathoracic (or disseminated) infection was observed in 12 patients (22%). Fifteen patients (27%) died with active coccidioidomycosis. Treatment of the hematologic disease with corticosteroids or antineoplastic chemotherapy increased the risk of death. CONCLUSION: To date, this is the largest case series of patients with hematologic malignancy and coccidioidomycosis. In persons with hematologic malignancy, coccidioidomycosis can be a severe illness with a high risk for disseminated infection and death.
Authors: Adrián Sánchez-Montalvá; Fernando Salvador; Isabel Ruiz-Camps; Pere Barba; David Valcárcel; Elena Sulleiro; Enrique Sanz-García; Israel Molina Journal: Am J Trop Med Hyg Date: 2016-10-17 Impact factor: 2.345
Authors: Michael Ke; Arash Heidari; Michael Valdez; Allen Tsiyer; Rasha Kuran; Royce Johnson Journal: J Investig Med High Impact Case Rep Date: 2022 Jan-Dec
Authors: Lindsey M Ward; Michael J Peluso; Jehan Z Budak; Brett M Elicker; Peter V Chin-Hong; Harry Lampiris; Jennifer S Mulliken Journal: BMJ Case Rep Date: 2020-04-29
Authors: Colin Fitterer; Zachary Berg; Thorvardur R Halfdanarson; Holenarasipur R Vikram; Shimon Kusne; Robert Orenstein; Maria Teresa Seville; Janis E Blair Journal: Mycopathologia Date: 2016-08-04 Impact factor: 3.785
Authors: Sandra Cecilia Garcia Garcia; Julio Cesar Salas Alanis; Minerva Gomez Flores; Sergio Eduardo Gonzalez Gonzalez; Lucio Vera Cabrera; Jorge Ocampo Candiani Journal: An Bras Dermatol Date: 2015 Sep-Oct Impact factor: 1.896