Literature DB >> 1564283

Platelet-derived growth factor in Dupuytren's disease.

M A Badalamente1, L C Hurst, S K Grandia, S P Sampson.   

Abstract

This study investigated whether platelet-derived growth factor, a potent inducer of cell proliferation, was identifiable in association with myofibroblasts in Dupuytren's disease. Myofibroblasts in the hypercellular disease stages showed a strong reaction to platelet-derived growth factor antibody using light and electron microscopic immunochemical labels. Platelet-derived growth factor may play a role as a cellular signal for myofibroblast proliferation in the formation of the pathognomonic nodule in Dupuytren's disease.

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Year:  1992        PMID： 1564283     DOI： 10.1016/0363-5023(92)90414-k

Source DB:  PubMed          Journal:  J Hand Surg Am        ISSN： 0363-5023            Impact factor:   2.230


  7 in total

Review 1.  Heterogeneity of myofibroblast phenotypic features: an example of fibroblastic cell plasticity.

Authors:  A Schmitt-Gräff; A Desmoulière; G Gabbiani
Journal:  Virchows Arch       Date:  1994       Impact factor: 4.064

2.  Microfilament system in the microvascular endothelium of the palmar fascia affected by mechanical stress applied from outside.

Authors:  G Brandes; E Reale; A Messina
Journal:  Virchows Arch       Date:  1996-10       Impact factor: 4.064

Review 3.  Scientific understanding and clinical management of Dupuytren disease.

Authors:  Barbara Shih; Ardeshir Bayat
Journal:  Nat Rev Rheumatol       Date:  2010-11-09       Impact factor: 20.543

Review 4.  Overview about the keloid scars and the elaboration of a non-invasive, unconventional treatment.

Authors:  Ingrid Carantino; Ioan Petre Florescu; Andrei Carantino
Journal:  J Med Life       Date:  2010 Apr-Jun

5.  In vitro study of novel collagenase (XIAFLEX®) on Dupuytren's disease fibroblasts displays unique drug related properties.

Authors:  Farhatullah Syed; Alexis N Thomas; Subir Singh; Venkatesh Kolluru; Susan G Emeigh Hart; Ardeshir Bayat
Journal:  PLoS One       Date:  2012-02-24       Impact factor: 3.240

Review 6.  Dupuytren's: a systems biology disease.

Authors:  Samrina Rehman; Royston Goodacre; Philip J Day; Ardeshir Bayat; Hans V Westerhoff
Journal:  Arthritis Res Ther       Date:  2011-09-12       Impact factor: 5.156

7.  Genome-wide analysis using exon arrays demonstrates an important role for expression of extra-cellular matrix, fibrotic control and tissue remodelling genes in Dupuytren's disease.

Authors:  Helen B Forrester; Peter Temple-Smith; Seungmin Ham; David de Kretser; Graeme Southwick; Carl N Sprung
Journal:  PLoS One       Date:  2013-03-12       Impact factor: 3.240
  7 in total

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