Literature DB >> 15642566

Effect of medical and surgical weight loss on endothelial vasomotor function in obese patients.

Noyan Gokce1, Joseph A Vita, Marie McDonnell, Armour R Forse, Nawfal Istfan, Maria Stoeckl, Izabella Lipinska, John F Keaney, Caroline M Apovian.   

Abstract

We prospectively examined brachial artery endothelial function using vascular ultrasound in 41 obese subjects treated with medical or surgical (gastric bypass) weight loss interventions. Surgical intervention produced greater weight loss and more pronounced improvement in endothelial function than medical treatment alone. Improved endothelial function with weight loss correlated strongly with fasting glucose but not with alteration in blood pressure, lipids, degree of weight loss, or plasma resistin concentrations. These data demonstrate that weight loss in markedly obese patients improves endothelial function and glycemic control that may represent important mechanisms of the cardiovascular benefit associated with weight reduction.

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Year:  2005        PMID： 15642566     DOI： 10.1016/j.amjcard.2004.09.016

Source DB:  PubMed          Journal:  Am J Cardiol        ISSN： 0002-9149            Impact factor:   2.778


  45 in total

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