| Literature DB >> 15642392 |
Harvindar Kaur Gill1, Ten Sew Keoh, Jasbir Singh Dhaliwal, Sarah Moore, Tan Sew Kim, Roshida Hassan, Faraiza Abdul Karim, Zubaidah Zakaria, Shahnaz Murad, Mahfuzah Mohamed, Caroline Mei Li Ho, Hishamshah Ibrahim, Eni Juraida Abdul Rahman.
Abstract
Eighty-eight multi-ethnic Malaysian pediatric acute lymphoblastic leukemia (ALL) patients were screened for the TEL-AML1 rearrangement by reverse transcription-polymerase chain reaction (RT-PCR). Fluorescence in situ hybridization (FISH) was used as an independent screen for 30 cases and to confirm RT-PCR positive cases. Seventeen patients, or 19%, were found to be t(12;21) positive. Ethnically the group comprised 12 Malays, 4 Chinese, and 1 Indian. All patients, including 1 with an unusual blast cell morphology who suffered an early relapse and death, were characteristic TEL-AML1 cases in cell count, age, ALL subset classification, and fusion transcript expressed. This study shows that in Malaysia, TEL-AML1 is found in the same distinct ALL subset and at a similar frequency as in other diverse childhood ALL cohorts.Entities:
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Year: 2005 PMID： 15642392 DOI： 10.1016/j.cancergencyto.2004.04.027
Source DB: PubMed Journal: Cancer Genet Cytogenet ISSN： 0165-4608