Literature DB >> 15642354

Structure-function analysis of a novel member of the LIV-1 subfamily of zinc transporters, ZIP14.

K M Taylor1, H E Morgan, A Johnson, R I Nicholson.   

Abstract

Here, we report the first investigation of a novel member of the LZT (LIV-1 subfamily of ZIP zinc Transporters) subfamily of zinc influx transporters. LZT subfamily sequences all contain a unique and highly conserved metalloprotease motif (HEXPHEXGD) in transmembrane domain V with both histidine residues essential for zinc transport by ZIP (Zrt-, Irt-like Proteins) transporters. We investigate here whether ZIP14 (SLC39A14), lacking the initial histidine in this motif, is still able to transport zinc. We demonstrate that this plasma membrane located glycosylated protein functions as a zinc influx transporter in a temperature-dependant manner.

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Year:  2005        PMID： 15642354     DOI： 10.1016/j.febslet.2004.12.006

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  76 in total

1.  The zinc transporter Zip14 influences c-Met phosphorylation and hepatocyte proliferation during liver regeneration in mice.

Authors:  Tolunay Beker Aydemir; Harry S Sitren; Robert J Cousins
Journal:  Gastroenterology       Date:  2012-02-25       Impact factor: 22.682

Review 2.  Zinc and liver disease.

Authors:  Mohammad K Mohammad; Mohammad K Mohommad; Zhanxiang Zhou; Matthew Cave; Ashutosh Barve; Craig J McClain
Journal:  Nutr Clin Pract       Date:  2012-02       Impact factor: 3.080

Review 3.  Glycosylation of solute carriers: mechanisms and functional consequences.

Authors:  Nis Borbye Pedersen; Michael C Carlsson; Stine Falsig Pedersen
Journal:  Pflugers Arch       Date:  2015-09-18       Impact factor: 3.657

Review 4.  Cellular and mitochondrial iron homeostasis in vertebrates.

Authors:  Caiyong Chen; Barry H Paw
Journal:  Biochim Biophys Acta       Date:  2012-01-18

Review 5.  The emerging role of the LIV-1 subfamily of zinc transporters in breast cancer.

Authors:  Kathryn M Taylor; Helen E Morgan; Kathryn Smart; Normawati M Zahari; Sara Pumford; Ian O Ellis; John F R Robertson; Robert I Nicholson
Journal:  Mol Med       Date:  2007 Jul-Aug       Impact factor: 6.354

Review 6.  Physiologic implications of metal-ion transport by ZIP14 and ZIP8.

Authors:  Supak Jenkitkasemwong; Chia-Yu Wang; Bryan Mackenzie; Mitchell D Knutson
Journal:  Biometals       Date:  2012-02-09       Impact factor: 2.949

7.  Slc39a1 to 3 (subfamily II) Zip genes in mice have unique cell-specific functions during adaptation to zinc deficiency.

Authors:  Taiho Kambe; Jim Geiser; Brett Lahner; David E Salt; Glen K Andrews
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2008-03-19       Impact factor: 3.619

Review 8.  Physiological roles of zinc transporters: molecular and genetic importance in zinc homeostasis.

Authors:  Takafumi Hara; Taka-Aki Takeda; Teruhisa Takagishi; Kazuhisa Fukue; Taiho Kambe; Toshiyuki Fukada
Journal:  J Physiol Sci       Date:  2017-01-27       Impact factor: 2.781

9.  Hypothyroidism induced by loss of the manganese efflux transporter SLC30A10 may be explained by reduced thyroxine production.

Authors:  Chunyi Liu; Steven Hutchens; Thomas Jursa; William Shawlot; Elena V Polishchuk; Roman S Polishchuk; Beth K Dray; Andrea C Gore; Michael Aschner; Donald R Smith; Somshuvra Mukhopadhyay
Journal:  J Biol Chem       Date:  2017-08-31       Impact factor: 5.157

10.  ZIP14 is degraded in response to manganese exposure.

Authors:  Khristy J Thompson; Marianne Wessling-Resnick
Journal:  Biometals       Date:  2019-09-20       Impact factor: 2.949
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