Literature DB >> 15642319

Sulfur in human crystallins.

Durga Srikanthan1, Orval A Bateman, Andrew G Purkiss, Christine Slingsby.   

Abstract

Molecular models of human gamma-crystallins and the 'alpha-crystallin domain' of human alphaA-crystallin have been built based on available related X-ray crystal structures. The accessibilities of the component cysteine, methionine and tryptophan side chains in the crystallin models have been calculated. The reactivities of these cysteines, which are oxidised in cataract, are assessed based on their known modifications and within the context of their location within the 3D models.

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Year:  2004        PMID： 15642319     DOI： 10.1016/j.exer.2004.05.009

Source DB:  PubMed          Journal:  Exp Eye Res        ISSN： 0014-4835            Impact factor:   3.467


  13 in total

1.  Aggregation of lens crystallins in an in vivo hyperbaric oxygen guinea pig model of nuclear cataract: dynamic light-scattering and HPLC analysis.

Authors:  M Francis Simpanya; Rafat R Ansari; Kwang I Suh; Victor R Leverenz; Frank J Giblin
Journal:  Invest Ophthalmol Vis Sci       Date:  2005-12       Impact factor: 4.799

2.  The molecular refractive function of lens γ-Crystallins.

Authors:  Huaying Zhao; Patrick H Brown; M Teresa Magone; Peter Schuck
Journal:  J Mol Biol       Date:  2011-06-12       Impact factor: 5.469

3.  Solution properties of γ-crystallins: hydration of fish and mammal γ-crystallins.

Authors:  Huaying Zhao; Yingwei Chen; Lenka Rezabkova; Zhengrong Wu; Graeme Wistow; Peter Schuck
Journal:  Protein Sci       Date:  2013-11-27       Impact factor: 6.725

4.  The cataract-associated R14C mutant of human gamma D-crystallin shows a variety of intermolecular disulfide cross-links: a Raman spectroscopic study.

Authors:  Ajay Pande; Darnelle Gillot; Jayanti Pande
Journal:  Biochemistry       Date:  2009-06-09       Impact factor: 3.162

5.  Structure and dynamics of the fish eye lens protein, γM7-crystallin.

Authors:  Bryon Mahler; Yingwei Chen; Jason Ford; Caleb Thiel; Graeme Wistow; Zhengrong Wu
Journal:  Biochemistry       Date:  2013-05-08       Impact factor: 3.162

6.  Reactive cysteine residues in the oxidative dimerization and Cu2+ induced aggregation of human γD-crystallin: Implications for age-related cataract.

Authors:  Srinivasagan Ramkumar; Xingjun Fan; Benlian Wang; Sichun Yang; Vincent M Monnier
Journal:  Biochim Biophys Acta Mol Basis Dis       Date:  2018-08-18       Impact factor: 5.187

Review 7.  Lens aging: effects of crystallins.

Authors:  K Krishna Sharma; Puttur Santhoshkumar
Journal:  Biochim Biophys Acta       Date:  2009-05-20

8.  Biophysical properties of gammaC-crystallin in human and mouse eye lens: the role of molecular dipoles.

Authors:  Andrew G Purkiss; Orval A Bateman; Keith Wyatt; Phillip A Wilmarth; Larry L David; Graeme J Wistow; Christine Slingsby
Journal:  J Mol Biol       Date:  2007-06-26       Impact factor: 5.469

9.  Shotgun proteomic analysis of S-thiolation sites of guinea pig lens nuclear crystallins following oxidative stress in vivo.

Authors:  Frank J Giblin; Larry L David; Phillip A Wilmarth; Victor R Leverenz; M Francis Simpanya
Journal:  Mol Vis       Date:  2013-02-03       Impact factor: 2.367

Review 10.  Redox chemistry of lens crystallins: A system of cysteines.

Authors:  Eugene Serebryany; David C Thorn; Liliana Quintanar
Journal:  Exp Eye Res       Date:  2021-07-29       Impact factor: 3.770
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