Literature DB >> 15641776

Precise epitope mapping of malaria parasite inhibitory antibodies by TROSY NMR cross-saturation.

William D Morgan1, Thomas A Frenkiel, Matthew J Lock, Munira Grainger, Anthony A Holder.   

Abstract

We have applied NMR cross-saturation with TROSY detection to the problem of precisely mapping conformational epitopes on complete protein antigen molecules. We have investigated complexes of the Fab fragments of two antibodies that have parasite inhibitory activity, bound to the important malaria vaccine candidate antigen, Plasmodium falciparum MSP1(19). The results indicate remarkable overlap between these epitopes for inhibitory antibodies, and will provide a basis for theoretical modeling of the antibody-antigen interface.

Entities:  

Mesh：

Substances：

Year:  2005        PMID： 15641776     DOI： 10.1021/bi0482957

Source DB:  PubMed          Journal:  Biochemistry        ISSN： 0006-2960            Impact factor:   3.162


  12 in total

1.  Plasmodium falciparum 19-kilodalton merozoite surface protein 1 (MSP1)-specific antibodies that interfere with parasite growth in vitro can inhibit MSP1 processing, merozoite invasion, and intracellular parasite development.

Authors:  David K Moss; Edmond J Remarque; Bart W Faber; David R Cavanagh; David E Arnot; Alan W Thomas; Anthony A Holder
Journal:  Infect Immun       Date:  2011-12-27       Impact factor: 3.441

Review 2.  Discovery of protective B-cell epitopes for development of antimicrobial vaccines and antibody therapeutics.

Authors:  Jacqueline Sharon; Michael J Rynkiewicz; Zhaohua Lu; Chiou-Ying Yang
Journal:  Immunology       Date:  2014-05       Impact factor: 7.397

3.  Biological activities of anti-merozoite surface protein-1 antibodies induced by adjuvant-assisted immunizations in mice with different immune gene knockouts.

Authors:  George Hui; Dan Choe; Caryn Hashimoto
Journal:  Clin Vaccine Immunol       Date:  2008-06-18

4.  Epitope mapping of PfCP-2.9, an asexual blood-stage vaccine candidate of Plasmodium falciparum.

Authors:  Changling Li; Rui Wang; Yuan Wu; Dongmei Zhang; Zhicheng He; Weiqing Pan
Journal:  Malar J       Date:  2010-04-12       Impact factor: 2.979

5.  Inhibition of erythrocyte invasion and Plasmodium falciparum merozoite surface protein 1 processing by human immunoglobulin G1 (IgG1) and IgG3 antibodies.

Authors:  Maria Lazarou; José A Guevara Patiño; Richard M Jennings; Richard S McIntosh; Jianguo Shi; Steven Howell; Eilish Cullen; Tarran Jones; Jaime R Adame-Gallegos; Jonathan A Chappel; Jana S McBride; Michael J Blackman; Anthony A Holder; Richard J Pleass
Journal:  Infect Immun       Date:  2009-10-05       Impact factor: 3.441

6.  Antimalarial activity of cupredoxins: the interaction of Plasmodium merozoite surface protein 119 (MSP119) and rusticyanin.

Authors:  Isabel Cruz-Gallardo; Irene Díaz-Moreno; Antonio Díaz-Quintana; Antonio Donaire; Adrián Velázquez-Campoy; Rachel D Curd; Kaveri Rangachari; Berry Birdsall; Andres Ramos; Anthony A Holder; Miguel A De la Rosa
Journal:  J Biol Chem       Date:  2013-06-07       Impact factor: 5.157

7.  Fine specificity of anti-MSP119 antibodies and multiplicity of Plasmodium falciparum merozoite surface protein 1 types in individuals in Nigeria with sub-microscopic infection.

Authors:  Josiane Ngoundou-Landji; Roseangela I Nwuba; Chiaka I Anumudu; Alexander B Odaibo; Wenceslas D Matondo Maya; Henrietta O Awobode; Christian M Okafor; Olajumoke A Morenikeji; Adanze Asinobi; Mark Nwagwu; Anthony A Holder; Francine Ntoumi
Journal:  Malar J       Date:  2010-10-18       Impact factor: 2.979

Review 8.  Biomolecular NMR: a chaperone to drug discovery.

Authors:  Marco Betz; Krishna Saxena; Harald Schwalbe
Journal:  Curr Opin Chem Biol       Date:  2006-05-05       Impact factor: 8.822

9.  Cellular responses to modified Plasmodium falciparum MSP119 antigens in individuals previously exposed to natural malaria infection.

Authors:  Christian M F Okafor; Chiaka I Anumudu; Yusuf O Omosun; Chairat Uthaipibull; Idowu Ayede; Henrietta O Awobode; Alex B Odaibo; Jean Langhorne; Anthony A Holder; Roseangela I Nwuba; Marita Troye-Blomberg
Journal:  Malar J       Date:  2009-11-23       Impact factor: 2.979

10.  The structure of Plasmodium yoelii merozoite surface protein 119, antibody specificity and implications for malaria vaccine design.

Authors:  Rachel D Curd; Berry Birdsall; Madhusudan Kadekoppala; Solabomi A Ogun; Geoffrey Kelly; Anthony A Holder
Journal:  Open Biol       Date:  2014-01-08       Impact factor: 6.411
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.