BACKGROUND: The anti-cyclic citrullinated peptide (CCP) test has a high sensitivity and specificity for rheumatoid arthritis, although CCP is not the physiological target of the autoantibodies. Citrullinated fibrin is abundant in inflamed synovium OBJECTIVE: To assess the diagnostic and prognostic value of antibodies against citrullinated fibrinogen (ACF), a soluble precursor of fibrin, in comparison with IgM-rheumatoid factor (IgM-RF) and the second generation anti-CCP test. METHODS: In 379 patients with early arthritis (258 rheumatoid and 121 undifferentiated), the sensitivity, specificity, and positive predictive value of ACF, anti-CCP, and IgM-RF for diagnosing rheumatoid arthritis were calculated. Multivariate logistic regression analysis was used to assess the diagnostic and prognostic value (radiographic progression after two years) of the tests. RESULTS: The sensitivities of the ACF, anti-CCP, and IgM-RF tests were 55.8%, 57.8%, and 44.6%, with specificities of 92.6%, 94.2%, and 96.7%, respectively. Approximately 30% of the IgM-RF negative patients were positive for ACF or anti-CCP or both. The ACF and anti-CCP test had a high agreement in early arthritis (kappa = 0.84). Of all baseline characteristics, the ACF test and the anti-CCP test were the best predictors for diagnosing rheumatoid arthritis at one year (odds ratio (OR) = 10.3 and 10.6, respectively) and for radiographic progression after two years (OR = 12.1 and 14.8). CONCLUSIONS: ACF is as sensitive as anti-CCP and more sensitive than IgM-RF in diagnosing rheumatoid arthritis in early arthritis. The ACF test is also a good predictor of radiographic progression, with a performance similar to the anti-CCP test. The ACF test and the anti-CCP test are especially valuable in IgM-RF negative arthritis.
BACKGROUND: The anti-cyclic citrullinated peptide (CCP) test has a high sensitivity and specificity for rheumatoid arthritis, although CCP is not the physiological target of the autoantibodies. Citrullinated fibrin is abundant in inflamed synovium OBJECTIVE: To assess the diagnostic and prognostic value of antibodies against citrullinated fibrinogen (ACF), a soluble precursor of fibrin, in comparison with IgM-rheumatoid factor (IgM-RF) and the second generation anti-CCP test. METHODS: In 379 patients with early arthritis (258 rheumatoid and 121 undifferentiated), the sensitivity, specificity, and positive predictive value of ACF, anti-CCP, and IgM-RF for diagnosing rheumatoid arthritis were calculated. Multivariate logistic regression analysis was used to assess the diagnostic and prognostic value (radiographic progression after two years) of the tests. RESULTS: The sensitivities of the ACF, anti-CCP, and IgM-RF tests were 55.8%, 57.8%, and 44.6%, with specificities of 92.6%, 94.2%, and 96.7%, respectively. Approximately 30% of the IgM-RF negative patients were positive for ACF or anti-CCP or both. The ACF and anti-CCP test had a high agreement in early arthritis (kappa = 0.84). Of all baseline characteristics, the ACF test and the anti-CCP test were the best predictors for diagnosing rheumatoid arthritis at one year (odds ratio (OR) = 10.3 and 10.6, respectively) and for radiographic progression after two years (OR = 12.1 and 14.8). CONCLUSIONS: ACF is as sensitive as anti-CCP and more sensitive than IgM-RF in diagnosing rheumatoid arthritis in early arthritis. The ACF test is also a good predictor of radiographic progression, with a performance similar to the anti-CCP test. The ACF test and the anti-CCP test are especially valuable in IgM-RF negative arthritis.
Authors: A Saraux; J M Berthelot; G Chalès; C Le Henaff; J B Thorel; S Hoang; I Valls; V Devauchelle; A Martin; D Baron; Y Pennec; E Botton; J Y Mary; P Le Goff; P Youinou Journal: Arthritis Rheum Date: 2001-11
Authors: C Masson-Bessière; M Sebbag; E Girbal-Neuhauser; L Nogueira; C Vincent; T Senshu; G Serre Journal: J Immunol Date: 2001-03-15 Impact factor: 5.422
Authors: L Nogueira; M Sebbag; C Vincent; M Arnaud; B Fournié; A Cantagrel; M Jolivet; G Serre Journal: Ann Rheum Dis Date: 2001-09 Impact factor: 19.103
Authors: C C Reparon-Schuijt; W J van Esch; C van Kooten; G A Schellekens; B A de Jong; W J van Venrooij; F C Breedveld; C L Verweij Journal: Arthritis Rheum Date: 2001-01
Authors: E J Kroot; B A de Jong; M A van Leeuwen; H Swinkels; F H van den Hoogen; M van't Hof; L B van de Putte; M H van Rijswijk; W J van Venrooij; P L van Riel Journal: Arthritis Rheum Date: 2000-08
Authors: R Goldbach-Mansky; J Lee; A McCoy; J Hoxworth; C Yarboro; J S Smolen; G Steiner; A Rosen; C Zhang; H A Ménard; Z J Zhou; T Palosuo; W J Van Venrooij ; R L Wilder; J H Klippel; H R Schumacher; H S El-Gabalawy Journal: Arthritis Res Date: 2000-03-31
Authors: Peggy P Ho; Lowen Y Lee; Xiaoyan Zhao; Beren H Tomooka; Ricardo T Paniagua; Orr Sharpe; Maya J BenBarak; Piyanka E Chandra; Wolfgang Hueber; Lawrence Steinman; William H Robinson Journal: J Immunol Date: 2009-11-30 Impact factor: 5.422
Authors: Frances Humby; Michele Bombardieri; Antonio Manzo; Stephen Kelly; Mark C Blades; Bruce Kirkham; Jo Spencer; Costantino Pitzalis Journal: PLoS Med Date: 2009-01-13 Impact factor: 11.069
Authors: Raimon Sanmartí; Eduard Graell; Maria L Perez; Guadalupe Ercilla; Odette Viñas; Jose A Gómez-Puerta; Jordi Gratacós; Alejandro Balsa; Maria J Gómara; Marta Larrosa; Juan D Cañete; Isabel Haro Journal: Arthritis Res Ther Date: 2009-09-02 Impact factor: 5.156
Authors: Carole L Galligan; Janet C Siebert; Katherine A Siminovitch; Edward C Keystone; Vivian Bykerk; Omar D Perez; Eleanor N Fish Journal: PLoS One Date: 2009-08-20 Impact factor: 3.240