| Literature DB >> 15639732 |
Matthias Leippe1, Heike Bruhn, Oliver Hecht, Joachim Grötzinger.
Abstract
The recently solved three-dimensional structure of amoebapore A, the major pore-forming protein of Entamoeba histolytica, represents the first tertiary structure determined from a parasitic toxin. The implications derived from this solved structure, together with biochemical data, paint a picture of a unique activation mechanism and reveal that a histidine-mediated dimerization of the protein acts as the molecular switch for the formation of oligomeric pores in target cell membranes.Entities:
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Year: 2005 PMID： 15639732 DOI： 10.1016/j.pt.2004.10.009
Source DB: PubMed Journal: Trends Parasitol ISSN： 1471-4922