| Literature DB >> 15639341 |
Yoshimitsu Niwa1, Kaoru Hirose, Keitaro Matsuo, Kazuo Tajima, Yoko Ikoma, Toru Nakanishi, Akihiro Nawa, Kazuo Kuzuya, Akiko Tamakoshi, Nobuyuki Hamajima.
Abstract
To examine the possible association between cervical cancer and Lymphotoxin-alpha (LT(alpha)) polymorphisms, C804A and A252G, an incident case-control study was conducted in Japanese. The cases were 131 cervical cancer patients. Controls were 320 healthy women. Risk estimation was conducted by an unconditional logistic model. Complete linkage disequilibrium was seen between LT(alpha) C804A and LT(alpha) A252G. We found that, compared with the 804CC genotype, 804CA and 804AA were associated with a decreased risk of cervical cancer (OR = 0.64, 95% CI = 0.40-1.02; and OR = 0.45, 95% CI = 0.21-0.95, respectively), especially of SCC (OR = 0.54, 95% CI = 0.32-0.91; and OR = 0.39, 95% CI = 0.16-0.92, respectively).Entities:
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Year: 2005 PMID： 15639341 DOI： 10.1016/j.canlet.2004.09.021
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679