Literature DB >> 15638801

Amphiphilic alpha-helical antimicrobial peptides and their structure/function relationships.

Sarah R Dennison1, James Wallace, Frederick Harris, David A Phoenix.   

Abstract

To facilitate microbial membrane invasion, amphiphilic alpha-helical antimicrobial peptides (alpha-AMPs) show a spatial segregation of hydrophobic and hydrophilic residues about the alpha-helical long axis. Here we discuss potential mechanisms by which these peptides are able to disrupt membrane structure and the structural characteristics, which are required for function.

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Year:  2005        PMID： 15638801     DOI： 10.2174/0929866053406084

Source DB:  PubMed          Journal:  Protein Pept Lett        ISSN： 0929-8665            Impact factor:   1.890


  31 in total

1.  Effects of net charge and the number of positively charged residues on the biological activity of amphipathic alpha-helical cationic antimicrobial peptides.

Authors:  Ziqing Jiang; Adriana I Vasil; John D Hale; Robert E W Hancock; Michael L Vasil; Robert S Hodges
Journal:  Biopolymers       Date:  2008       Impact factor: 2.505

2.  Bioactivity and the first transmission electron microscopy immunogold studies of short de novo-designed antimicrobial peptides.

Authors:  Marisa Ann Azad; Heidi Esther Katrina Huttunen-Hennelly; Cynthia Ross Friedman
Journal:  Antimicrob Agents Chemother       Date:  2011-02-07       Impact factor: 5.191

3.  Structure-activity analysis of the dermcidin-derived peptide DCD-1L, an anionic antimicrobial peptide present in human sweat.

Authors:  Maren Paulmann; Thomas Arnold; Dirk Linke; Suat Özdirekcan; Annika Kopp; Thomas Gutsmann; Hubert Kalbacher; Ines Wanke; Verena J Schuenemann; Michael Habeck; Jochen Bürck; Anne S Ulrich; Birgit Schittek
Journal:  J Biol Chem       Date:  2012-01-18       Impact factor: 5.157

4.  Separation and identification of bromelain-generated antibacterial peptides from Actinopyga lecanora.

Authors:  Raheleh Ghanbari; Afshin Ebrahimpour
Journal:  Food Sci Biotechnol       Date:  2017-12-12       Impact factor: 2.391

5.  Anti-tuberculosis activity of α-helical antimicrobial peptides: de novo designed L- and D-enantiomers versus L- and D-LL-37.

Authors:  Ziqing Jiang; Michael P Higgins; James Whitehurst; Kevin O Kisich; Martin I Voskuil; Robert S Hodges
Journal:  Protein Pept Lett       Date:  2011-03       Impact factor: 1.890

6.  The effect of C-terminal amidation on the efficacy and selectivity of antimicrobial and anticancer peptides.

Authors:  Sarah Rachel Dennison; Frederick Harris; Tailap Bhatt; Jaipaul Singh; David Andrew Phoenix
Journal:  Mol Cell Biochem       Date:  2009-06-10       Impact factor: 3.396

7.  Single Amino Acid Substitutions at Specific Positions of the Heptad Repeat Sequence of Piscidin-1 Yielded Novel Analogs That Show Low Cytotoxicity and In Vitro and In Vivo Antiendotoxin Activity.

Authors:  Amit Kumar; Amit Kumar Tripathi; Manoj Kathuria; Sonal Shree; Jitendra Kumar Tripathi; R K Purshottam; Ravishankar Ramachandran; Kalyan Mitra; Jimut Kanti Ghosh
Journal:  Antimicrob Agents Chemother       Date:  2016-05-23       Impact factor: 5.191

Review 8.  Structure, membrane orientation, mechanism, and function of pexiganan--a highly potent antimicrobial peptide designed from magainin.

Authors:  Lindsey M Gottler; Ayyalusamy Ramamoorthy
Journal:  Biochim Biophys Acta       Date:  2008-10-29

9.  Variations in amino acid composition of antisense peptide-phosphorodiamidate morpholino oligomer affect potency against Escherichia coli in vitro and in vivo.

Authors:  Brett L Mellbye; Susan E Puckett; Luke D Tilley; Patrick L Iversen; Bruce L Geller
Journal:  Antimicrob Agents Chemother       Date:  2008-11-17       Impact factor: 5.191

10.  Effects of Hydrophobic Amino Acid Substitutions on Antimicrobial Peptide Behavior.

Authors:  Kimberly D Saint Jean; Karlee D Henderson; Christina L Chrom; Louisa E Abiuso; Lindsay M Renn; Gregory A Caputo
Journal:  Probiotics Antimicrob Proteins       Date:  2018-09       Impact factor: 4.609
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