Literature DB >> 15638729

Bioisosterism: a useful strategy for molecular modification and drug design.

Lídia Moreira Lima1, Eliezer J Barreiro.   

Abstract

Mesh：

Year:  2005        PMID： 15638729     DOI： 10.2174/0929867053363540

Source DB:  PubMed          Journal:  Curr Med Chem        ISSN： 0929-8673            Impact factor:   4.530


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  75 in total

1.  Successful identification of key chemical structure modifications that lead to improved ADME profiles.

Authors:  Lourdes Cucurull-Sanchez
Journal:  J Comput Aided Mol Des       Date:  2010-05-09       Impact factor: 3.686

2.  Synthesis, antimitotic and antivascular activity of 1-(3',4',5'-trimethoxybenzoyl)-3-arylamino-5-amino-1,2,4-triazoles.

Authors:  Romeo Romagnoli; Pier Giovanni Baraldi; Maria Kimatrai Salvador; Filippo Prencipe; Valerio Bertolasi; Michela Cancellieri; Andrea Brancale; Ernest Hamel; Ignazio Castagliuolo; Francesca Consolaro; Elena Porcù; Giuseppe Basso; Giampietro Viola
Journal:  J Med Chem       Date:  2014-07-28       Impact factor: 7.446

3.  Discovery of New Selenoureido Analogues of 4-(4-Fluorophenylureido)benzenesulfonamide as Carbonic Anhydrase Inhibitors.

Authors:  Andrea Angeli; Damiano Tanini; Thomas S Peat; Lorenzo Di Cesare Mannelli; Gianluca Bartolucci; Antonella Capperucci; Carla Ghelardini; Claudiu T Supuran; Fabrizio Carta
Journal:  ACS Med Chem Lett       Date:  2017-08-10       Impact factor: 4.345

4.  Anti-inflammatory effect of a new piperazine derivative: (4-methylpiperazin-1-yl)(1-phenyl-1H-pyrazol-4-yl)methanone.

Authors:  Daniel C Batista; Daiany P B Silva; Iziara F Florentino; Carina S Cardoso; Merita P Gonçalves; Marize C Valadares; Luciano M Lião; Germán Sanz; Boniek G Vaz; Elson A Costa; Ricardo Menegatti
Journal:  Inflammopharmacology       Date:  2017-08-20       Impact factor: 4.473

5.  Synthesis of alkenyldiarylmethanes (ADAMs) containing benzo[d]isoxazole and oxazolidin-2-one rings, a new series of potent non-nucleoside HIV-1 reverse transcriptase inhibitors.

Authors:  Bo-Liang Deng; Yujie Zhao; Tracy L Hartman; Karen Watson; Robert W Buckheit; Christophe Pannecouque; Erik De Clercq; Mark Cushman
Journal:  Eur J Med Chem       Date:  2008-09-19       Impact factor: 6.514

Review 6.  Leishmaniasis treatment--a challenge that remains: a review.

Authors:  Dilvani O Santos; Carlos E R Coutinho; Maria F Madeira; Carolina G Bottino; Rodrigo T Vieira; Samara B Nascimento; Alice Bernardino; Saulo C Bourguignon; Suzana Corte-Real; Rosa T Pinho; Carlos Rangel Rodrigues; Helena C Castro
Journal:  Parasitol Res       Date:  2008-06       Impact factor: 2.289

7.  Design, synthesis and prostate cancer cell-based studies of analogs of the Rho/MKL1 transcriptional pathway inhibitor, CCG-1423.

Authors:  Chris R Evelyn; Jessica L Bell; Jenny G Ryu; Susan M Wade; Andrew Kocab; Nicole L Harzdorf; H D Showalter; Richard R Neubig; Scott D Larsen
Journal:  Bioorg Med Chem Lett       Date:  2009-11-18       Impact factor: 2.823

8.  Silicon Incorporated Morpholine Antifungals: Design, Synthesis, and Biological Evaluation.

Authors:  Gorakhnath R Jachak; Remya Ramesh; Duhita G Sant; Shweta U Jorwekar; Manjusha R Jadhav; Santosh G Tupe; Mukund V Deshpande; D Srinivasa Reddy
Journal:  ACS Med Chem Lett       Date:  2015-09-22       Impact factor: 4.345

9.  Design, Synthesis, and Identification of Silicon Incorporated Oxazolidinone Antibiotics with Improved Brain Exposure.

Authors:  B Seetharamsingh; Remya Ramesh; Santoshkumar S Dange; Pankaj V Khairnar; Smita Singhal; Dilip Upadhyay; Sridhar Veeraraghavan; Srikant Viswanadha; Swaroop Vakkalanka; D Srinivasa Reddy
Journal:  ACS Med Chem Lett       Date:  2015-10-26       Impact factor: 4.345

10.  Synthetically modified bioisosteres of salicyl alcohol and their gastroulcerogenic assessment versus aspirin: biochemical and histological correlates.

Authors:  Gowhar Ali; Fazal Subhan; Nazar Ul Islam; Nasir Ullah; Robert D E Sewell; Muhammad Shahid; Ikhtiar Khan
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2013-11-29       Impact factor: 3.000
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