Literature DB >> 15638728

Protein tyrosine phosphatases and their inhibitors.

Purushottam M Dewang1, Nai-Mu Hsu, Shao-Zheng Peng, Wen-Ren Li.   

Abstract

Protein tyrosine phosphatase (PTP) is the family of enzymes that are key players in cellular signal transduction system and perturbation in their functioning is implicated in many disease-states. Diverse chemical compounds are being synthesized and evaluated as PTP inhibitors. This review presents a brief account of various enzymes of the PTP family and their inhibitors. Peculiar features of these enzymes and their roles in various diseases are summarized along with important inhibitors developed in recent years.

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Year:  2005        PMID： 15638728     DOI： 10.2174/0929867053363504

Source DB:  PubMed          Journal:  Curr Med Chem        ISSN： 0929-8673            Impact factor:   4.530


  10 in total

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Authors:  Andrew M Riley; Melanie Trusselle; Paul Kuad; Michal Borkovec; Jaiesoon Cho; Jae H Choi; Xun Qian; Stephen B Shears; Bernard Spiess; Barry V L Potter
Journal:  Chembiochem       Date:  2006-07       Impact factor: 3.164

2.  Development of molecular probes for second-site screening and design of protein tyrosine phosphatase inhibitors.

Authors:  Jesus Vazquez; Lutz Tautz; Jennifer J Ryan; Kristiina Vuori; Tomas Mustelin; Maurizio Pellecchia
Journal:  J Med Chem       Date:  2007-03-30       Impact factor: 7.446

3.  Identification of novel, less toxic PTP-LAR inhibitors using in silico strategies: pharmacophore modeling, SADMET-based virtual screening and docking.

Authors:  Dara Ajay; M Elizabeth Sobhia
Journal:  J Mol Model       Date:  2011-04-27       Impact factor: 1.810

4.  Pleiotrophin disrupts calcium-dependent homophilic cell-cell adhesion and initiates an epithelial-mesenchymal transition.

Authors:  P Perez-Pinera; S Alcantara; T Dimitrov; J A Vega; T F Deuel
Journal:  Proc Natl Acad Sci U S A       Date:  2006-11-10       Impact factor: 11.205

5.  Ternary oxovanadium(IV) complexes of ONO-donor Schiff base and polypyridyl derivatives as protein tyrosine phosphatase inhibitors: synthesis, characterization, and biological activities.

Authors:  Caixia Yuan; Liping Lu; Xiaoli Gao; Yanbo Wu; Maolin Guo; Ying Li; Xueqi Fu; Miaoli Zhu
Journal:  J Biol Inorg Chem       Date:  2009-03-17       Impact factor: 3.358

6.  Inhibitors of Src homology-2 domain containing protein tyrosine phosphatase-2 (Shp2) based on oxindole scaffolds.

Authors:  Harshani R Lawrence; Roberta Pireddu; Liwei Chen; Yunting Luo; Shen-Shu Sung; Ann Marie Szymanski; M L Richard Yip; Wayne C Guida; Saïd M Sebti; Jie Wu; Nicholas J Lawrence
Journal:  J Med Chem       Date:  2008-08-05       Impact factor: 7.446

7.  Microarray analysis of choroid/RPE gene expression in marmoset eyes undergoing changes in ocular growth and refraction.

Authors:  Lilian Shelton; David Troilo; Megan R Lerner; Yuriy Gusev; Daniel J Brackett; Jody Summers Rada
Journal:  Mol Vis       Date:  2008-08-11       Impact factor: 2.367

Review 8.  5,8-Quinolinedione Scaffold as a Promising Moiety of Bioactive Agents.

Authors:  Monika Kadela-Tomanek; Ewa Bębenek; Elwira Chrobak; Stanisław Boryczka
Journal:  Molecules       Date:  2019-11-14       Impact factor: 4.411

Review 9.  Approaches to Decrease Hyperglycemia by Targeting Impaired Hepatic Glucose Homeostasis Using Medicinal Plants.

Authors:  Gerardo Mata-Torres; Adolfo Andrade-Cetto; Fernanda Espinoza-Hernández
Journal:  Front Pharmacol       Date:  2021-12-23       Impact factor: 5.810

10.  The protein-phosphatome of the human malaria parasite Plasmodium falciparum.

Authors:  Jonathan M Wilkes; Christian Doerig
Journal:  BMC Genomics       Date:  2008-09-15       Impact factor: 3.969
  10 in total

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