Literature DB >> 15638246

Phospholipase D-catalyzed synthesis of novel phospholipid-phytosterol conjugates.

Monjur Hossen1, Ernesto Hernandez.   

Abstract

In the present study, plant sterols were modified to form amphiphiles by synthesizing phospholipid derivatives from them so they could be formulated in different functional foods and possibly improve their effects as therapeutic agents. The new phosphatidyl derivatives, phosphatidyl-sitosterols, were synthesized by the transfer reaction of a phosphatidyl residue from PC to beta-sitosterol by phospholipase D (PLD EC 3.1.4.4) from Streptomyces sp. in a biphasic medium.

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Year:  2004        PMID： 15638246     DOI： 10.1007/s11745-004-1295-2

Source DB:  PubMed          Journal:  Lipids        ISSN： 0024-4201            Impact factor:   1.880


  14 in total

1.  Phospholipase D-catalyzed transphosphatidylation in anhydrous organic solvents.

Authors:  J O Rich; Y L Khmelnitsky
Journal:  Biotechnol Bioeng       Date:  2001-02-05       Impact factor: 4.530

2.  Plant sterol and stanol margarines and health.

Authors:  M Law
Journal:  BMJ       Date:  2000-03-25

3.  Reduction of blood cholesterol in man.

Authors:  O J POLLAK
Journal:  Circulation       Date:  1953-05       Impact factor: 29.690

4.  Effect of soybean sterols in the diet on plasma and liver cholesterol in chicks.

Authors:  D W PETERSON
Journal:  Proc Soc Exp Biol Med       Date:  1951-10

5.  Effects of plant stanol esters supplied in low-fat yoghurt on serum lipids and lipoproteins, non-cholesterol sterols and fat soluble antioxidant concentrations.

Authors:  Ronald P Mensink; Spike Ebbing; Martijn Lindhout; Jogchum Plat; Marjolien M A van Heugten
Journal:  Atherosclerosis       Date:  2002-01       Impact factor: 5.162

6.  Spreads enriched with three different levels of vegetable oil sterols and the degree of cholesterol lowering in normocholesterolaemic and mildly hypercholesterolaemic subjects.

Authors:  H F Hendriks; J A Weststrate; T van Vliet; G W Meijer
Journal:  Eur J Clin Nutr       Date:  1999-04       Impact factor: 4.016

7.  Influence of phytostanol phosphoryl ascorbate, FM-VP4, on pancreatic lipase activity and cholesterol accumulation within Caco-2 cells.

Authors:  Manisha Ramaswamy; Edwin Yau; Kishor M Wasan; Kathy D Boulanger; Ming Li; P Haydn Pritchard
Journal:  J Pharm Pharm Sci       Date:  2002 Jan-Apr       Impact factor: 2.327

8.  Effect of phytosterols and phytostanols on the solubilization of cholesterol by dietary mixed micelles: an in vitro study.

Authors:  Sergey M Mel'nikov; Jack W M Seijen ten Hoorn; Astrid P A M Eijkelenboom
Journal:  Chem Phys Lipids       Date:  2004-02       Impact factor: 3.329

9.  Plant sterol-fortified orange juice effectively lowers cholesterol levels in mildly hypercholesterolemic healthy individuals.

Authors:  Sridevi Devaraj; Ishwarlal Jialal; Sonia Vega-López
Journal:  Arterioscler Thromb Vasc Biol       Date:  2004-02-05       Impact factor: 8.311

10.  Plant sterol-enriched margarines and reduction of plasma total- and LDL-cholesterol concentrations in normocholesterolaemic and mildly hypercholesterolaemic subjects.

Authors:  J A Weststrate; G W Meijer
Journal:  Eur J Clin Nutr       Date:  1998-05       Impact factor: 4.016
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