OBJECTIVE: Cytomegalovirus (CMV), Helicobacter pylori (H. pylori) and Chlamydia pneumoniae (C. pneumoniae) have been associated with human atherosclerosis. The reported rates of detection within atherosclerotic lesions by PCR vary widely for all of these pathogens. We investigated their presence in carotid atherosclerotic plaques. METHODS AND RESULTS: Eighty-three carotid atherosclerotic specimens were available for examination. The highly sensitive polymerase chain reaction method was employed with primers specific for each agent. The presence of CMV DNA was not detected in any of the examined samples (0%), whereas the presence of H. pylori DNA was observed in two out of eighty-three cases (2.4%). C. pneumoniae DNA was found in eighteen (21.6%) of the plaques studied. CONCLUSIONS: H. pylori DNA was detected in a very small subset of atherosclerotic plaques, whereas CMV DNA was not detected in any of the plaques studied. C. pneumoniae DNA was found in a significant number of our atherosclerotic plaques. Further studies are needed to clarify the possible causal relation between infection by these organisms and atherosclerosis.
OBJECTIVE: Cytomegalovirus (CMV), Helicobacter pylori (H. pylori) and Chlamydia pneumoniae (C. pneumoniae) have been associated with humanatherosclerosis. The reported rates of detection within atherosclerotic lesions by PCR vary widely for all of these pathogens. We investigated their presence in carotid atherosclerotic plaques. METHODS AND RESULTS: Eighty-three carotid atherosclerotic specimens were available for examination. The highly sensitive polymerase chain reaction method was employed with primers specific for each agent. The presence of CMV DNA was not detected in any of the examined samples (0%), whereas the presence of H. pylori DNA was observed in two out of eighty-three cases (2.4%). C. pneumoniae DNA was found in eighteen (21.6%) of the plaques studied. CONCLUSIONS:H. pylori DNA was detected in a very small subset of atherosclerotic plaques, whereas CMV DNA was not detected in any of the plaques studied. C. pneumoniae DNA was found in a significant number of our atherosclerotic plaques. Further studies are needed to clarify the possible causal relation between infection by these organisms and atherosclerosis.
Authors: E Podsiadły; J Przyłuski; A Kwiatkowski; M Kruk; M Wszoła; R Nosek; W Rowiński; W Ruzyłło; S Tylewska-Wierzbanowska Journal: Eur J Clin Microbiol Infect Dis Date: 2005-08 Impact factor: 3.267
Authors: Dimas T Ikeoka; Carolina Z Vieira; Pedro A Lemos; Tania V Strabelli; Expedito E Ribeiro da Silva; Marco A Perin; Andrea Groselj-Strele; Beate Tiran; Andreas Tiran; Bruno Caramelli Journal: Clin Res Cardiol Date: 2008-10-13 Impact factor: 5.460
Authors: Gorm Mørk Hansen; Martin Nilsson; Claus Henrik Nielsen; Palle Holmstrup; Steffen Helqvist; Tim Tolker-Nielsen; Michael Givskov; Peter Riis Hansen Journal: PLoS One Date: 2015-12-22 Impact factor: 3.240