New inhibitor against nuclear factor of activated T cells transcription from Ribes fasciculatum var. chinense.

Two new compounds were isolated from the stem and twigs of Ribes fasciculatum var. chinense and their structures were identified to be threo-(7S,8R)-1-(4-hydroxyphenyl)-2-[4-(E)-propenylphenoxy]-propan-1-ol (1), and 5,4'-dihydroxy-7-methoxyflavone-3-O-[alpha-L-rhamnopyranosyl(1-->3)-O-alpha-L-rhamnopyranosyl(1-->6)-O-beta-D-glucopyranoside] (2). With nine other known components, they were tested on inhibitory activity against nuclear factor of activated T cells (NFAT) transcription factor. Compound 1 showed a potent inhibitory activity (IC50=15.6 microM), while compounds 4, 5 and 9 showed moderate inhibitory activity (IC50 22.4, 24.5 and 25.7 microM, respectively).