BACKGROUND: Cessation of smoking after a cardiovascular event has been shown in Western countries to have a beneficial effect on clinical events during long-term follow-up. However, knowledge of the effect of smoking status after acute myocardial infarction (AMI) on the long-term mortality based on a large-scale sample is still limited in Japan. METHODS AND RESULTS: In the present study 2,579 AMI patients were enrolled in the Osaka Acute Coronary Insufficiency Study (OACIS) between April 1998 and March 2003. Smoking status was assessed at baseline and 3 months after hospital discharge by mailed questionnaire. Patients were divided into nonsmokers (n=823), former smokers (those who had stopped smoking before AMI onset, n=332), quitters (those who stopped smoking after AMI onset, n=1,056), and persistent smokers (those who smoked before and after AMI, n=368). Quitters had lower long-term mortality rates than persistent smokers (3.0% vs 5.2%; log rank, p=0.032). Multivariate Cox regression analysis revealed that smoking cessation was independently associated with a reduction in risk of long-term mortality (hazard ratio, 0.39; 95% confidence interval, 0.20-0.77). CONCLUSIONS: Patients who continue to smoke after AMI are at greater risk for death than patients who quit smoking. Cessation of smoking benefits the long-term prognosis in patients with AMI.
BACKGROUND: Cessation of smoking after a cardiovascular event has been shown in Western countries to have a beneficial effect on clinical events during long-term follow-up. However, knowledge of the effect of smoking status after acute myocardial infarction (AMI) on the long-term mortality based on a large-scale sample is still limited in Japan. METHODS AND RESULTS: In the present study 2,579 AMI patients were enrolled in the Osaka Acute Coronary Insufficiency Study (OACIS) between April 1998 and March 2003. Smoking status was assessed at baseline and 3 months after hospital discharge by mailed questionnaire. Patients were divided into nonsmokers (n=823), former smokers (those who had stopped smoking before AMI onset, n=332), quitters (those who stopped smoking after AMI onset, n=1,056), and persistent smokers (those who smoked before and after AMI, n=368). Quitters had lower long-term mortality rates than persistent smokers (3.0% vs 5.2%; log rank, p=0.032). Multivariate Cox regression analysis revealed that smoking cessation was independently associated with a reduction in risk of long-term mortality (hazard ratio, 0.39; 95% confidence interval, 0.20-0.77). CONCLUSIONS:Patients who continue to smoke after AMI are at greater risk for death than patients who quit smoking. Cessation of smoking benefits the long-term prognosis in patients with AMI.
Authors: G J Arason; J Kramer; B Blaskó; R Kolka; P Thorbjornsdottir; K Einarsdóttir; A Sigfúsdóttir; S T Sigurdarson; G Sigurdsson; Z Rónai; Z Prohászka; M Sasvári-Székely; S Bödvarsson; G Thorgeirsson; G Füst Journal: Clin Exp Immunol Date: 2007-04-11 Impact factor: 4.330
Authors: David W Biery; Adam N Berman; Avinainder Singh; Sanjay Divakaran; Ersilia M DeFilippis; Bradley L Collins; Ankur Gupta; Amber Fatima; Arman Qamar; Josh Klein; Jon Hainer; Michael J Blaha; Marcelo F Di Carli; Khurram Nasir; Deepak L Bhatt; Ron Blankstein Journal: JAMA Netw Open Date: 2020-07-01
Authors: Matias B Yudi; Omar Farouque; Nick Andrianopoulos; Andrew E Ajani; Katie Kalten; Angela L Brennan; Jeffrey Lefkovits; Chin Hiew; Ernesto Oqueli; Christopher M Reid; Stephen J Duffy; David J Clark Journal: BMJ Open Date: 2017-10-06 Impact factor: 2.692