Literature DB >> 15635017

Cryptococcus neoformans isolates from transplant recipients are not selected for resistance to calcineurin inhibitors by current immunosuppressive regimens.

Jill R Blankenship1, Nina Singh, Barbara D Alexander, Joseph Heitman.   

Abstract

The immunosuppressants tacrolimus (FK506) and cyclosporine A inhibit calcineurin and have potent antifungal activity. In this study, 24% of Cryptococcus neoformans isolates from solid-organ transplant patients exhibited altered sensitivity to these drugs, which may have an impact on the infectious course but does not appear to be the consequence of immunosuppressive therapy.

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Year:  2005        PMID： 15635017      PMCID： PMC540157          DOI： 10.1128/JCM.43.1.464-467.2005

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  37 in total

1.  The immunosuppressant FK506 and its nonimmunosuppressive analog L-685,818 are toxic to Cryptococcus neoformans by inhibition of a common target protein.

Authors:  A Odom; M Del Poeta; J Perfect; J Heitman
Journal:  Antimicrob Agents Chemother       Date:  1997-01       Impact factor: 5.191

2.  Ca2+-calmodulin promotes survival of pheromone-induced growth arrest by activation of calcineurin and Ca2+-calmodulin-dependent protein kinase.

Authors:  M J Moser; J R Geiser; T N Davis
Journal:  Mol Cell Biol       Date:  1996-09       Impact factor: 4.272

3.  FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin.

Authors:  S J O'Keefe; J Tamura; R L Kincaid; M J Tocci; E A O'Neill
Journal:  Nature       Date:  1992-06-25       Impact factor: 49.962

4.  Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A.

Authors:  D A Fruman; C B Klee; B E Bierer; S J Burakoff
Journal:  Proc Natl Acad Sci U S A       Date:  1992-05-01       Impact factor: 11.205

5.  Cryptococcal meningitis after liver transplantation.

Authors:  N Jabbour; J Reyes; S Kusne; M Martin; J Fung
Journal:  Transplantation       Date:  1996-01-15       Impact factor: 4.939

6.  Calcineurin is essential in cyclosporin A- and FK506-sensitive yeast strains.

Authors:  T Breuder; C S Hemenway; N R Movva; M E Cardenas; J Heitman
Journal:  Proc Natl Acad Sci U S A       Date:  1994-06-07       Impact factor: 11.205

Review 7.  Fungal infections in solid-organ transplantation.

Authors:  C V Paya
Journal:  Clin Infect Dis       Date:  1993-05       Impact factor: 9.079

8.  Complementation of a capsule-deficient mutation of Cryptococcus neoformans restores its virulence.

Authors:  Y C Chang; K J Kwon-Chung
Journal:  Mol Cell Biol       Date:  1994-07       Impact factor: 4.272

9.  Targets of immunophilin-immunosuppressant complexes are distinct highly conserved regions of calcineurin A.

Authors:  M E Cardenas; R S Muir; T Breuder; J Heitman
Journal:  EMBO J       Date:  1995-06-15       Impact factor: 11.598

10.  Protein phosphatase type 2B (calcineurin)-mediated, FK506-sensitive regulation of intracellular ions in yeast is an important determinant for adaptation to high salt stress conditions.

Authors:  T Nakamura; Y Liu; D Hirata; H Namba; S Harada; T Hirokawa; T Miyakawa
Journal:  EMBO J       Date:  1993-11       Impact factor: 11.598
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  8 in total

Review 1.  Antifungal adjuvants: Preserving and extending the antifungal arsenal.

Authors:  Arielle Butts; Glen E Palmer; P David Rogers
Journal:  Virulence       Date:  2016-07-26       Impact factor: 5.882

Review 2.  Regulatory circuitry governing fungal development, drug resistance, and disease.

Authors:  Rebecca S Shapiro; Nicole Robbins; Leah E Cowen
Journal:  Microbiol Mol Biol Rev       Date:  2011-06       Impact factor: 11.056

3.  Role of a CUF1/CTR4 copper regulatory axis in the virulence of Cryptococcus neoformans.

Authors:  Scott R Waterman; Moshe Hacham; Guowu Hu; Xudong Zhu; Yoon-Dong Park; Soowan Shin; John Panepinto; Tibor Valyi-Nagy; Craig Beam; Shahid Husain; Nina Singh; Peter R Williamson
Journal:  J Clin Invest       Date:  2007-02-08       Impact factor: 14.808

4.  Emergence and pathogenicity of highly virulent Cryptococcus gattii genotypes in the northwest United States.

Authors:  Edmond J Byrnes; Wenjun Li; Yonathan Lewit; Hansong Ma; Kerstin Voelz; Ping Ren; Dee A Carter; Vishnu Chaturvedi; Robert J Bildfell; Robin C May; Joseph Heitman
Journal:  PLoS Pathog       Date:  2010-04-22       Impact factor: 6.823

Review 5.  Cryptococcosis in solid organ transplant recipients: current state of the science.

Authors:  Nina Singh; Francoise Dromer; John R Perfect; Olivier Lortholary
Journal:  Clin Infect Dis       Date:  2008-11-15       Impact factor: 9.079

6.  Genome variation in Cryptococcus gattii, an emerging pathogen of immunocompetent hosts.

Authors:  C A D'Souza; J W Kronstad; G Taylor; R Warren; M Yuen; G Hu; W H Jung; A Sham; S E Kidd; K Tangen; N Lee; T Zeilmaker; J Sawkins; G McVicker; S Shah; S Gnerre; A Griggs; Q Zeng; K Bartlett; W Li; X Wang; J Heitman; J E Stajich; J A Fraser; W Meyer; D Carter; J Schein; M Krzywinski; K J Kwon-Chung; A Varma; J Wang; R Brunham; M Fyfe; B F F Ouellette; A Siddiqui; M Marra; S Jones; R Holt; B W Birren; J E Galagan; C A Cuomo
Journal:  MBio       Date:  2011-02-08       Impact factor: 7.867

7.  Genetic and genomic architecture of the evolution of resistance to antifungal drug combinations.

Authors:  Jessica A Hill; Ron Ammar; Dax Torti; Corey Nislow; Leah E Cowen
Journal:  PLoS Genet       Date:  2013-04-04       Impact factor: 5.917

8.  First reported case of Cryptococcus gattii in the Southeastern USA: implications for travel-associated acquisition of an emerging pathogen.

Authors:  Edmond J Byrnes; Wenjun Li; Yonathan Lewit; John R Perfect; Dee A Carter; Gary M Cox; Joseph Heitman
Journal:  PLoS One       Date:  2009-06-10       Impact factor: 3.240
  8 in total

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