Metastasising pituitary neuroendocrinal tumour with peptide secretion.

A 26-year-old male presented with prolactin-secreting invasive pituitary macroadenoma, which was partially excised with right pterional craniotomy. Post-operative computerized tomography revealed persistence of the tumour and hence he was started on oral bromocriptine therapy. His therapeutic compliance was poor. Seven years later he presented with further increase in size of the pituitary macroadenoma with hepatic and gastric metastasis. Upper gastrointestinal endoscopic biopsy of the metastatic lesions and immunohistochemical staining diagnosed it as a neuroendocrinal tumour with peptide secretion. He was initially treated with oral bromocriptine alone and later along with octreotide.