Literature DB >> 15631440

Efficient generation of 2'-deoxyuridin-5-yl at 5'-(G/C)AA(X)U(X)U-3' (X = Br, I) sequences in duplex DNA under UV irradiation.

Takayoshi Watanabe1, Toshikazu Bando, Yan Xu, Ryu Tashiro, Hiroshi Sugiyama.   

Abstract

The photoreactivity of 5-halouracil-containing DNA was investigated using 450 base pair DNA fragments under 302 nm irradiation. Heat-dependent cleavage selectively occurs at 5'-(G/C)AAXUXU-3' and 5'-(G/C)AXUXU-3' (X = Br, I) sequences in double-stranded DNA. HPLC product analysis indicated that 2'-deoxyribonolactone residues are effectively generated at these sequences. These observations will be useful in studying the molecular basis of the sequence-dependent DNA-damaging process in UV-irradiated 5-halouracil-containing DNA.

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Year:  2005        PMID： 15631440     DOI： 10.1021/ja0454743

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  11 in total

1.  An investigation into the mechanisms of DNA strand breakage by direct ionization of variably hydrated plasmid DNA.

Authors:  Shubhadeep Purkayastha; Jamie R Milligan; William A Bernhard
Journal:  J Phys Chem B       Date:  2006-12-28       Impact factor: 2.991

2.  Facile photocyclization chemistry of 5-phenylthio-2'-deoxyuridine in duplex DNA.

Authors:  Yu Zeng; Huachuan Cao; Yinsheng Wang
Journal:  Org Lett       Date:  2006-06-08       Impact factor: 6.005

3.  Photoreactivation of DNA by an archaeal nucleoprotein Sso7d.

Authors:  Ryu Tashiro; Andrew H-J Wang; Hiroshi Sugiyama
Journal:  Proc Natl Acad Sci U S A       Date:  2006-10-30       Impact factor: 11.205

4.  Reactivity of Nucleic Acid Radicals.

Authors:  Marc M Greenberg
Journal:  Adv Phys Org Chem       Date:  2016       Impact factor: 2.833

Review 5.  Mass Spectrometry-Based Protein Footprinting for Higher-Order Structure Analysis: Fundamentals and Applications.

Authors:  Xiaoran Roger Liu; Mengru Mira Zhang; Michael L Gross
Journal:  Chem Rev       Date:  2020-04-22       Impact factor: 60.622

6.  Low-energy electron-induced damage in a trinucleotide containing 5-bromouracil.

Authors:  Zejun Li; Pierre Cloutier; Léon Sanche; J Richard Wagner
Journal:  J Phys Chem B       Date:  2011-11-01       Impact factor: 2.991

Review 7.  Photoreaction of DNA Containing 5-Halouracil and its Products.

Authors:  Ryu Tashiro; Hiroshi Sugiyama
Journal:  Photochem Photobiol       Date:  2021-10-05       Impact factor: 3.521

8.  DNA damage and interstrand cross-link formation upon irradiation of aryl iodide C-nucleotide analogues.

Authors:  Hui Ding; Marc M Greenberg
Journal:  J Org Chem       Date:  2010-02-05       Impact factor: 4.354

9.  Enzymatic synthesis of long double-stranded DNA labeled with haloderivatives of nucleobases in a precisely pre-determined sequence.

Authors:  Ireneusz Sobolewski; Katarzyna Polska; Agnieszka Zylicz-Stachula; Joanna Jeżewska-Frąckowiak; Janusz Rak; Piotr Skowron
Journal:  BMC Biochem       Date:  2011-08-24       Impact factor: 4.059

10.  X-ray and UV Radiation Damage of dsDNA/Protein Complexes.

Authors:  Paweł Wityk; Dorota Kostrzewa-Nowak; Beata Krawczyk; Michał Michalik; Robert Nowak
Journal:  Molecules       Date:  2021-05-24       Impact factor: 4.411
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