OBJECTIVES: To assess symptoms associated with Helicobacter pylori infection in children presenting with nonulcer dyspepsia (NUD). STUDY DESIGN: A prospective double-blind study was conducted between March 2001 and April 2002 in children at least 6 years old with NUD who had been referred for upper gastrointestinal endoscopy for epigastric pain. A standardized questionnaire was administered blindly by a pediatric gastroenterologist. This questionnaire characterized epigastric pain and associated factors. Infection was confirmed by positive culture and histologic examination of the gastric mucosa. RESULTS: From 100 children enrolled, 26 proved infected (12 female, 14 male; mean age: 11.4 +/- 2.6 years), and 74 were noninfected (44 female, 30 male; mean age: 10.4 +/- 3.1 years). There were no differences in age or symptom characteristics between groups except for epigastric pain during meals that was more frequent in noninfected than in infected children (25.6% vs 3.8%). CONCLUSION: There were no specific characteristics of symptoms in nonulcer-dyspeptic H pylori-infected children as compared with noninfected children.
RCT Entities:
OBJECTIVES: To assess symptoms associated with Helicobacter pyloriinfection in children presenting with nonulcer dyspepsia (NUD). STUDY DESIGN: A prospective double-blind study was conducted between March 2001 and April 2002 in children at least 6 years old with NUD who had been referred for upper gastrointestinal endoscopy for epigastric pain. A standardized questionnaire was administered blindly by a pediatric gastroenterologist. This questionnaire characterized epigastric pain and associated factors. Infection was confirmed by positive culture and histologic examination of the gastric mucosa. RESULTS: From 100 children enrolled, 26 proved infected (12 female, 14 male; mean age: 11.4 +/- 2.6 years), and 74 were noninfected (44 female, 30 male; mean age: 10.4 +/- 3.1 years). There were no differences in age or symptom characteristics between groups except for epigastric pain during meals that was more frequent in noninfected than in infected children (25.6% vs 3.8%). CONCLUSION: There were no specific characteristics of symptoms in nonulcer-dyspeptic H pylori-infectedchildren as compared with noninfected children.
Authors: N Kalach; S Papadopoulos; E Asmar; C Spyckerelle; P Gosset; J Raymond; E Dehecq; A Decoster; C Creusy; C Dupont Journal: Dig Dis Sci Date: 2008-11-12 Impact factor: 3.199