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Literature DB >> 15629725

A kinase-independent function of Cks1 and Cdk1 in regulation of transcription.

Veronica P C C Yu¹, Chris Baskerville, Björn Grünenfelder, Steven I Reed.

Abstract

We describe a function in transcription for the Saccharomyces cerevisiae cell cycle regulatory cyclin-dependent kinase Cdc28 (Cdk1) and its interacting protein, Cks1. The Cks1/Cdc28 complex is recruited to multiple coding regions in the genome and is necessary for efficient expression of a significant subset of genes. This transcriptional role is mediated through a requirement of Cdc28/Cks1 for recruiting proteasomes to coding regions. However, it is independent of the protein kinase activity of Cdc28. In the absence of Cks1, neither Cdc28 nor the proteasome can be recruited. Consequently, there is a failure to maintain efficient transcription.

Entities: Chemical

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Year: 2005 PMID： 15629725 DOI： 10.1016/j.molcel.2004.11.020

Source DB: PubMed Journal: Mol Cell ISSN： 1097-2765 Impact factor: 17.970

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Cited

29 in total

1. Similar temporal and spatial recruitment of native 19S and 20S proteasome subunits to transcriptionally active chromatin.

Authors: Fuqiang Geng; William P Tansey
Journal: Proc Natl Acad Sci U S A Date: 2012-04-02 Impact factor: 11.205

2. SCFCdc4 enables mating type switching in yeast by cyclin-dependent kinase-mediated elimination of the Ash1 transcriptional repressor.

Authors: Qingquan Liu; Brett Larsen; Marketa Ricicova; Stephen Orlicky; Hille Tekotte; Xiaojing Tang; Karen Craig; Adam Quiring; Thierry Le Bihan; Carl Hansen; Frank Sicheri; Mike Tyers
Journal: Mol Cell Biol Date: 2010-11-22 Impact factor: 4.272

3. Chemical inhibition of the TFIIH-associated kinase Cdk7/Kin28 does not impair global mRNA synthesis.

Authors: Elenita I Kanin; Ryan T Kipp; Charles Kung; Matthew Slattery; Agnes Viale; Steven Hahn; Kevan M Shokat; Aseem Z Ansari
Journal: Proc Natl Acad Sci U S A Date: 2007-03-28 Impact factor: 11.205

4. CKS Proteins Promote Checkpoint Recovery by Stimulating Phosphorylation of Treslin.

Authors: Ruiling Mu; John Tat; Robert Zamudio; Yaoyang Zhang; John R Yates; Akiko Kumagai; William G Dunphy; Steven I Reed
Journal: Mol Cell Biol Date: 2017-09-26 Impact factor: 4.272

5. Elucidating the druggable interface of protein-protein interactions using fragment docking and coevolutionary analysis.

Authors: Fang Bai; Faruck Morcos; Ryan R Cheng; Hualiang Jiang; José N Onuchic
Journal: Proc Natl Acad Sci U S A Date: 2016-11-29 Impact factor: 11.205

10. Cyclin-dependent kinase-associated proteins Cks1 and Cks2 are essential during early embryogenesis and for cell cycle progression in somatic cells.

Authors: Hanna-Stina Martinsson-Ahlzén; Vasco Liberal; Björn Grünenfelder; Susana R Chaves; Charles H Spruck; Steven I Reed
Journal: Mol Cell Biol Date: 2008-07-14 Impact factor: 4.272

A kinase-independent function of Cks1 and Cdk1 in regulation of transcription.

1. Similar temporal and spatial recruitment of native 19S and 20S proteasome subunits to transcriptionally active chromatin.

2. SCFCdc4 enables mating type switching in yeast by cyclin-dependent kinase-mediated elimination of the Ash1 transcriptional repressor.

3. Chemical inhibition of the TFIIH-associated kinase Cdk7/Kin28 does not impair global mRNA synthesis.

4. CKS Proteins Promote Checkpoint Recovery by Stimulating Phosphorylation of Treslin.

5. Elucidating the druggable interface of protein-protein interactions using fragment docking and coevolutionary analysis.

6. Cdc28 kinase activity regulates the basal transcription machinery at a subset of genes.

7. Cks1 enhances transcription efficiency at the GAL1 locus by linking the Paf1 complex to the 19S proteasome.

8. Systematic localization of the Arabidopsis core cell cycle proteins reveals novel cell division complexes.

9. Morphogenesis signaling components influence cell cycle regulation by cyclin dependent kinase.

10. Cyclin-dependent kinase-associated proteins Cks1 and Cks2 are essential during early embryogenesis and for cell cycle progression in somatic cells.