Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 HAP1 and intracellular trafficking.

Literature DB >> 15629196

HAP1 and intracellular trafficking.

Abstract

Huntington's disease is caused by a polyglutamine expansion in the protein huntingtin. Several studies suggest that huntingtin and its associated protein HAP1 participate in intracellular trafficking and that polyglutamine expansion affects vesicular transport. A study now provides new evidence that HAP1 is also involved in the endocytosis of membrane receptors. These studies offer insight into the normal function of HAP1 and its involvement in Huntington's disease.

Entities: Chemical Disease Gene

Mesh：

Substances：

Year: 2005 PMID： 15629196 DOI： 10.1016/j.tips.2004.11.001

Source DB: PubMed Journal: Trends Pharmacol Sci ISSN： 0165-6147 Impact factor: 14.819

Keyword Cloud
Cited

29 in total

1. Disrupted GABAAR trafficking and synaptic inhibition in a mouse model of Huntington's disease.

Authors: Eunice Y Yuen; Jing Wei; Ping Zhong; Zhen Yan
Journal: Neurobiol Dis Date: 2012-02-28 Impact factor: 5.996

Review 2. Energy deficit in Huntington disease: why it matters.

Authors: Fanny Mochel; Ronald G Haller
Journal: J Clin Invest Date: 2011-02-01 Impact factor: 14.808

Review 3. Shaping the role of mitochondria in the pathogenesis of Huntington's disease.

Authors: Veronica Costa; Luca Scorrano
Journal: EMBO J Date: 2012-03-23 Impact factor: 11.598

4. Loss of Ahi1 affects early development by impairing BM88/Cend1-mediated neuronal differentiation.

Authors: Ling Weng; Yung-Feng Lin; Alina L Li; Chuan-En Wang; Sen Yan; Miao Sun; Marta A Gaertig; Naureen Mitha; Jun Kosaka; Taketoshi Wakabayashi; Xingshun Xu; Beisha Tang; Shihua Li; Xiao-Jiang Li
Journal: J Neurosci Date: 2013-05-08 Impact factor: 6.167

9. Huntingtin regulates RE1-silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF) nuclear trafficking indirectly through a complex with REST/NRSF-interacting LIM domain protein (RILP) and dynactin p150 Glued.

Authors: Masahito Shimojo
Journal: J Biol Chem Date: 2008-10-15 Impact factor: 5.157

10. Huntingtin-associated protein 1 regulates exocytosis, vesicle docking, readily releasable pool size and fusion pore stability in mouse chromaffin cells.

Authors: Kimberly D Mackenzie; Michael D Duffield; Heshan Peiris; Lucy Phillips; Mark P Zanin; Ee Hiok Teo; Xin-Fu Zhou; Damien J Keating
Journal: J Physiol Date: 2013-12-23 Impact factor: 5.182

HAP1 and intracellular trafficking.

1. Disrupted GABAAR trafficking and synaptic inhibition in a mouse model of Huntington's disease.

Review 2. Energy deficit in Huntington disease: why it matters.

Review 3. Shaping the role of mitochondria in the pathogenesis of Huntington's disease.

4. Loss of Ahi1 affects early development by impairing BM88/Cend1-mediated neuronal differentiation.

5. Immunohistochemical localization of huntingtin-associated protein 1 in endocrine system of the rat.

6. HAP1 helps to regulate actin-based transport of insulin-containing granules in pancreatic β cells.

7. Selective expression of Huntingtin-associated protein 1 in {beta}-cells of the rat pancreatic islets.

8. Regulation of L-type Ca2+ Channel Activity and Insulin Secretion by Huntingtin-associated Protein 1.

9. Huntingtin regulates RE1-silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF) nuclear trafficking indirectly through a complex with REST/NRSF-interacting LIM domain protein (RILP) and dynactin p150 Glued.

10. Huntingtin-associated protein 1 regulates exocytosis, vesicle docking, readily releasable pool size and fusion pore stability in mouse chromaffin cells.