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Literature DB >> 15627039

Antiretroviral therapy with tenofovir is associated with mild renal dysfunction.

Stefan Mauss¹, Florian Berger, Guenther Schmutz.

Abstract

A cross-sectional study was conducted to compare patients treated with tenofovir with patients never treated with tenofovir. Patients on tenofovir showed a lower mean glomerular filtration rate estimated by creatinine clearance or cystatin C clearance compared with control patients. In total, 24 patients on tenofovir versus five control patients had proteinuria greater than 130 mg/day. In the majority of patients on tenofovir proteinuria was of tubular origin.

Entities: Chemical Disease Gene Species

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Year: 2005 PMID： 15627039 DOI： 10.1097/00002030-200501030-00012

Source DB: PubMed Journal: AIDS ISSN： 0269-9370 Impact factor: 4.177

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Cited

24 in total

1. In vitro cytotoxicity and mitochondrial toxicity of tenofovir alone and in combination with other antiretrovirals in human renal proximal tubule cells.

Authors: Francesc Vidal; Joan Carles Domingo; Jordi Guallar; Maria Saumoy; Begoña Cordobilla; Rainel Sánchez de la Rosa; Marta Giralt; Maria Luisa Alvarez; Miguel López-Dupla; Ferran Torres; Francesc Villarroya; Tomas Cihlar; Pere Domingo
Journal: Antimicrob Agents Chemother Date: 2006-08-28 Impact factor: 5.191

2. The effects of cotrimoxazole or tenofovir co-administration on the pharmacokinetics of maraviroc in healthy volunteers.

Authors: Samantha Abel; Deborah Russell; Lyndsey A Whitlock; Caroline E Ridgway; Gary J Muirhead
Journal: Br J Clin Pharmacol Date: 2008-04 Impact factor: 4.335

3. Proteinuria and endothelial dysfunction in stable HIV-infected patients. A pilot study.

Authors: Samir K Gupta; Kieren J Mather; Rajiv Agarwal; Chandan K Saha; Robert V Considine; Michael P Dubé
Journal: J Acquir Immune Defic Syndr Date: 2007-08-15 Impact factor: 3.731

4. Factors associated with renal dysfunction within an urban HIV-infected cohort in the era of highly active antiretroviral therapy.

Authors: E T Overton; D Nurutdinova; J Freeman; W Seyfried; K E Mondy
Journal: HIV Med Date: 2009-03-11 Impact factor: 3.180

Antiretroviral therapy with tenofovir is associated with mild renal dysfunction.

1. In vitro cytotoxicity and mitochondrial toxicity of tenofovir alone and in combination with other antiretrovirals in human renal proximal tubule cells.

2. The effects of cotrimoxazole or tenofovir co-administration on the pharmacokinetics of maraviroc in healthy volunteers.

3. Proteinuria and endothelial dysfunction in stable HIV-infected patients. A pilot study.

4. Factors associated with renal dysfunction within an urban HIV-infected cohort in the era of highly active antiretroviral therapy.

5. Contribution of metabolic and anthropometric abnormalities to cardiovascular disease risk factors.

6. Incidence and risk factors for tenofovir-associated renal toxicity in HIV-infected patients.

7. Cystatin C level as a marker of kidney function in human immunodeficiency virus infection: the FRAM study.

8. Cystatin C and creatinine in an HIV cohort: the nutrition for healthy living study.

Review 9. Renal disease in patients with HIV infection: epidemiology, pathogenesis and management.

10. Renal function with use of a tenofovir-containing initial antiretroviral regimen.