OBJECTIVE: To examine interleukin-2 (IL-2) activity,serum soluble IL-2 receptor (sIL-2R) level and T lymphocyte subsets in peripheral blood from 63 childhood iron deficiency anemia (IDA) patients with recurrent respiratory infections(RRI). METHODS: IL-2 activity, sIL-2R level and T lymphocyte subsets were assayed by MTT, ELISA and APAAP, respectively. RESULTS: IL-2 activity, percentages of CD3+ and CD4+ cells as well as the ratio of CD4+/ CD8+ cells in the patients were significantly lower ( P < 0.01),while sIL-2R levels were higher than that in normal controls (P < 0.01). No significant change was found in the percentage of CD8+ cells. CONCLUSION: Cellular immunity was impaired in childhood IDA with RRI.
OBJECTIVE: To examine interleukin-2 (IL-2) activity,serum soluble IL-2 receptor (sIL-2R) level and T lymphocyte subsets in peripheral blood from 63 childhood iron deficiency anemia (IDA) patients with recurrent respiratory infections(RRI). METHODS:IL-2 activity, sIL-2R level and T lymphocyte subsets were assayed by MTT, ELISA and APAAP, respectively. RESULTS:IL-2 activity, percentages of CD3+ and CD4+ cells as well as the ratio of CD4+/ CD8+ cells in the patients were significantly lower ( P < 0.01),while sIL-2R levels were higher than that in normal controls (P < 0.01). No significant change was found in the percentage of CD8+ cells. CONCLUSION: Cellular immunity was impaired in childhood IDA with RRI.
Authors: Mohammad Reza Keramati; Mohammad Hadi Sadeghian; Hossein Ayatollahi; Mahmoud Mahmoudi; Mohammad Khajedaluea; Houman Tavasolian; Anahita Borzouei Journal: Malays J Med Sci Date: 2011-01