OBJECTIVE: To observe the efficacy and side effects of allogeneic bone marrow transplantation (allo-BMT) in the treatment of malignant histiocytosis (MH). METHODS: After conditioning with chemotherapy and total body irradiation, HLA-A, B, DR, DQ compatible allo-BMT was performed in a patient with MH. RESULTS: DNA fingerprinting showed engraftment on day 22, bone marrow aspiration showed hypercellularity on day 50, and no abnormal cell was found. The patient developed acute graft-versus-host disease ( II degrees) on day 40 and herpes zoster 6 months post-transplantation, and the patient has survived disease-freely for 24 months after allo-BMT. CONCLUSION: This is the first report of treatment of MH with allo-BMT in China, showing that allo-BMT may significantly prolong the survival of MH.
OBJECTIVE: To observe the efficacy and side effects of allogeneic bone marrow transplantation (allo-BMT) in the treatment of malignant histiocytosis (MH). METHODS: After conditioning with chemotherapy and total body irradiation, HLA-A, B, DR, DQ compatible allo-BMT was performed in a patient with MH. RESULTS: DNA fingerprinting showed engraftment on day 22, bone marrow aspiration showed hypercellularity on day 50, and no abnormal cell was found. The patient developed acute graft-versus-host disease ( II degrees) on day 40 and herpes zoster 6 months post-transplantation, and the patient has survived disease-freely for 24 months after allo-BMT. CONCLUSION: This is the first report of treatment of MH with allo-BMT in China, showing that allo-BMT may significantly prolong the survival of MH.
Authors: A Abu-Sanad; A Warsi; R P Michel; A Nahal; G Popradi; J M Storring; A S Liberman; T Alcindor Journal: Curr Oncol Date: 2012-08 Impact factor: 3.677
Authors: Amer Zeidan; Javier Bolaños-Meade; Yvette Kasamon; Joseph Aoki; Michael Borowitz; Lode Swinnen; Heather Symons; Leo Luznik; Ephraim Fuchs; Richard Jones; Richard Ambinder Journal: Leuk Lymphoma Date: 2012-08-27