| Literature DB >> 15624999 |
Kristin E Price1, Steven J Broadwater, Hyun M Jung, D Tyler McQuade.
Abstract
Using reaction rate data collected in aprotic solvents, we have determined that the Baylis-Hillman rate-determining step is second order in aldehyde and first order in DABCO and acrylate. On the basis of these data, we have proposed a new mechanism involving a hemiacetal intermediate. The proposed mechanism was then supported using two different kinetic isotope experiments.Entities:
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Year: 2005 PMID： 15624999 DOI： 10.1021/ol047739o
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005