Collagenfleece as a bioimplant for orthopedic surgery.

Man-made bone implant materials as substitutes for autogenic spongiosa transplantation are reviewed, specifically materials made from collagen. The intra- and extracellular biosynthesis of collagen is described. Manufacture, properties and indications of sterile Collagen-fleece, a well proven surgical biomaterial prepared from porcine collagen, is presented. Further research led to the development of a new bone-replacement material called Collapat.