OBJECTIVE: To establish the progression of brain atrophy rates in patients with a known date of onset of Alzheimer disease (AD). METHODS: Each of 18 subjects had two high-resolution T1-weighted three-dimensional MRI examinations. The two MRIs were coregistered and the annual rate of brain tissue atrophy was derived both for the entire brain and regionally for the left and right medial temporal lobe (MTL). Time since onset (TSO) of AD, defined as the interval between the date of onset and the midpoint of MRI dates, ranged from -2.9 to 4.2 years. RESULTS: In patients with AD, TSO was a correlate of the atrophy rate for both the left MTL (R2 = 0.58, p = 0.001) and right MTL (R2 = 0.30, p = 0.03). When serial measurements were applied to a control group of 21 cognitively normal elderly subjects, MTL atrophy rate classified the group membership (AD vs normal cognition) with an accuracy of 92.3%. CONCLUSION: Increased annual atrophy rate in the medial temporal lobe is a potential diagnostic marker of the progression of Alzheimer disease.
OBJECTIVE: To establish the progression of brain atrophy rates in patients with a known date of onset of Alzheimer disease (AD). METHODS: Each of 18 subjects had two high-resolution T1-weighted three-dimensional MRI examinations. The two MRIs were coregistered and the annual rate of brain tissue atrophy was derived both for the entire brain and regionally for the left and right medial temporal lobe (MTL). Time since onset (TSO) of AD, defined as the interval between the date of onset and the midpoint of MRI dates, ranged from -2.9 to 4.2 years. RESULTS: In patients with AD, TSO was a correlate of the atrophy rate for both the left MTL (R2 = 0.58, p = 0.001) and right MTL (R2 = 0.30, p = 0.03). When serial measurements were applied to a control group of 21 cognitively normal elderly subjects, MTL atrophy rate classified the group membership (AD vs normal cognition) with an accuracy of 92.3%. CONCLUSION: Increased annual atrophy rate in the medial temporal lobe is a potential diagnostic marker of the progression of Alzheimer disease.
Authors: Lubov E Zeifman; William F Eddy; Oscar L Lopez; Lewis H Kuller; Cyrus Raji; Paul M Thompson; James T Becker Journal: J Alzheimers Dis Date: 2015 Impact factor: 4.472
Authors: Ranjan Duara; David A Loewenstein; Maria T Greig-Custo; Ashok Raj; Warren Barker; Elizabeth Potter; Elizabeth Schofield; Brent Small; John Schinka; Yougui Wu; Huntington Potter Journal: Int J Geriatr Psychiatry Date: 2010-03 Impact factor: 3.485
Authors: Mert R Sabuncu; Rahul S Desikan; Jorge Sepulcre; Boon Thye T Yeo; Hesheng Liu; Nicholas J Schmansky; Martin Reuter; Michael W Weiner; Randy L Buckner; Reisa A Sperling; Bruce Fischl Journal: Arch Neurol Date: 2011-08
Authors: Jiong Zhan; Miroslaw Brys; Lidia Glodzik; Wai Tsui; Elizabeth Javier; Jerzy Wegiel; Izabela Kuchna; Elizabeth Pirraglia; Yi Li; Lisa Mosconi; Leslie A Saint Louis; Remigiusz Switalski; Susan De Santi; Byeong C Kim; Thomas Wisniewski; Barry Reisberg; Matthew Bobinski; Mony J de Leon Journal: Hum Brain Mapp Date: 2009-03 Impact factor: 5.038