OBJECTIVE: For further investigating the efficacy and side effects of meisoindico. METHODS: Four handred and two cases of chronic myelogenous leukemia (CML) were treated with meisoindico alone on the dosage of 75-150mg/day. RESULTS: The total response rate was 90.1% and the complete and partial remission rates were 81.3%. The effect was better in patients with newly diagnosed CML than in those previously treated. The major side effects were bone, joint and muscle pain of varying degrees. No impairment of cardiac, renal and hepatic function were found. None of the patients developed severe myelosuppression. CONCLUSION: Meisoindico is a novel effective drug for CML.
OBJECTIVE: For further investigating the efficacy and side effects of meisoindico. METHODS: Four handred and two cases of chronic myelogenous leukemia (CML) were treated with meisoindico alone on the dosage of 75-150mg/day. RESULTS: The total response rate was 90.1% and the complete and partial remission rates were 81.3%. The effect was better in patients with newly diagnosed CML than in those previously treated. The major side effects were bone, joint and muscle pain of varying degrees. No impairment of cardiac, renal and hepatic function were found. None of the patients developed severe myelosuppression. CONCLUSION: Meisoindico is a novel effective drug for CML.
Authors: David M Lucas; Patrick C Still; Lynette Bueno Pérez; Michael R Grever; A Douglas Kinghorn Journal: Curr Drug Targets Date: 2010-07 Impact factor: 3.465