| Literature DB >> 15621432 |
Hassan Hajjaj1, Philippe Duboc, Laurent B Fay, Irène Zbinden, Katherine Macé, Peter Niederberger.
Abstract
The formation of cholesterol synthesis inhibiting molecules by five different strains of the koji mold Aspergillus oryzae was studied. After growing these strains on a complex liquid medium we found in crude organic phase extracts and specific fractions there from compounds inhibiting cholesterol synthesis in human hepatic T9A4 cells in vitro at enzyme sites downstream of dihydrolanosterol. This was evidenced by using different radioactively labeled precursors, namely acetate, mevalonate, 24,25-dihydro-[24,25-(3)H2]-lanosterol or [3-(3)H]-lathosterol.Entities:
Mesh：
Substances：
Year: 2005 PMID： 15621432 DOI： 10.1016/j.femsle.2004.11.001
Source DB: PubMed Journal: FEMS Microbiol Lett ISSN： 0378-1097 Impact factor: 2.742