| Literature DB >> 15620683 |
Balázs Visegrády1, Dénes Lorinczy, Gábor Hild, Béla Somogyi, Miklós Nyitrai.
Abstract
The stabilisation of magnesium actin filaments by phalloidin and jasplakinolide was studied using the method of differential scanning calorimetry. The results showed that actin could adapt three conformations in the presence of drugs. One conformation was adapted in direct interaction with the drug, while another conformation was identical to that observed in the absence of drugs. A third conformation was induced through allosteric inter-protomer interactions. The effect of both drugs propagated cooperatively along the actin filaments. The number of the cooperative units determined by using a quantitative model was larger for jasplakinolide (15 actin protomers) than for phalloidin (7 protomers).Entities:
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Year: 2005 PMID： 15620683 DOI： 10.1016/j.febslet.2004.11.023
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124