Literature DB >> 15620270

Meroterpenoid MAPKAP (MK2) inhibitors isolated from the indonesian marine sponge Acanthodendrilla sp.

David E Williams1, Jean-Baptiste Telliez, Julie Liu, Akbar Tahir, Rob van Soest, Raymond J Andersen.   

Abstract

(+)-Makassaric acid (1) and (+)-subersic acid (2), new meroterpenoid inhibitors of the protein kinase MK2, have been isolated from the marine sponge Acanthodendrilla sp. collected in Indonesia. The structures of (+)-makassaric acid (1) and (+)-subersic acid (2) were determined by spectroscopic analysis.

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Year:  2004        PMID： 15620270     DOI： 10.1021/np049808d

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  10 in total

Review 1.  Marine pharmacology in 2003-4: marine compounds with anthelmintic antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiplatelet, antiprotozoal, antituberculosis, and antiviral activities; affecting the cardiovascular, immune and nervous systems, and other miscellaneous mechanisms of action.

Authors:  Alejandro M S Mayer; Abimael D Rodríguez; Roberto G S Berlinck; Mark T Hamann
Journal:  Comp Biochem Physiol C Toxicol Pharmacol       Date:  2007-02-09       Impact factor: 3.228

2.  Inhibition of the protein kinase MK-2 protects podocytes from nephrotic syndrome-related injury.

Authors:  Ruma Pengal; Adam J Guess; Shipra Agrawal; Joshua Manley; Richard F Ransom; Robert J Mourey; Rainer Benndorf; William E Smoyer
Journal:  Am J Physiol Renal Physiol       Date:  2011-05-25

Review 3.  Biological activities of meroterpenoids isolated from different sources.

Authors:  Neeraj Kumar Fuloria; Radhika K Raheja; Kaushal H Shah; Manisha J Oza; Yogesh A Kulkarni; Vetriselvan Subramaniyan; Mahendran Sekar; Shivkanya Fuloria
Journal:  Front Pharmacol       Date:  2022-09-19       Impact factor: 5.988

4.  Exploring Short and Efficient Synthetic Routes Using Titanocene(III)-Catalyzed Reactions: Total Synthesis of Natural Meroterpenes with Trisubstituted Unsaturations.

Authors:  Jennifer Rosales; Gustavo Cabrera; José Justicia
Journal:  Molecules       Date:  2022-04-08       Impact factor: 4.927

5.  Marine natural meroterpenes: synthesis and antiproliferative activity.

Authors:  Annabel Simon-Levert; Christophe Menniti; Laurent Soulère; Anne-Marie Genevière; Chantal Barthomeuf; Bernard Banaigs; Anne Witczak
Journal:  Mar Drugs       Date:  2010-02-23       Impact factor: 5.118

6.  Controlling the Mdm2-Mdmx-p53 Circuit.

Authors:  David L Waning; Jason A Lehman; Christopher N Batuello; Lindsey D Mayo
Journal:  Pharmaceuticals (Basel)       Date:  2010-05-18

Review 7.  Targeting Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAPK2, MK2): Medicinal Chemistry Efforts To Lead Small Molecule Inhibitors to Clinical Trials.

Authors:  Mario Fiore; Stefano Forli; Fabrizio Manetti
Journal:  J Med Chem       Date:  2015-11-09       Impact factor: 7.446

Review 8.  Kinase inhibitors from marine sponges.

Authors:  Danielle Skropeta; Natalie Pastro; Ana Zivanovic
Journal:  Mar Drugs       Date:  2011-10-24       Impact factor: 6.085

Review 9.  Marine Sponges and Bacteria as Challenging Sources of Enzyme Inhibitors for Pharmacological Applications.

Authors:  Nadia Ruocco; Susan Costantini; Flora Palumbo; Maria Costantini
Journal:  Mar Drugs       Date:  2017-06-12       Impact factor: 5.118

Review 10.  Meroterpenes from marine invertebrates: structures, occurrence, and ecological implications.

Authors:  Marialuisa Menna; Concetta Imperatore; Filomena D'Aniello; Anna Aiello
Journal:  Mar Drugs       Date:  2013-05-17       Impact factor: 5.118
  10 in total

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