[The changes and relation among platelet function, plasma heparin and anti-coagulation-III: activity in patients with hemorrhagic fever with renal syndrome].

Blood platelet count (BPC), platelet adhesive rate (PAdT), platelet aggregate rate (PAgT), plasma heparin and anti-coagulation-III: activity (AT-III: alpha) were determined in 55 cases with hemorrhagic fever with renal syndrome (HFRS). In these patients, decreased BPC, defect PAdT, PAgT, increased plasma heparin as well as decreased AT-III: a were found, moreover, these changes were much notable in patients with severe type. A positive correlation existed between plasma heparin and BPC, PAdT, PAgT in cases with 80% AT-III: alpha or above (r values were -0.4344, -.7157 and -0.5547 respectly, p<0.01). The results suggested that plasma heparin may be one of factors resulting in decreased BPC and defect platelet function in HFRS patients with 80% AT-III: alpha or above.